Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bimatoprost
Drug ID BADD_D00274
Description Bimatoprost, also known as Latisse or Lumigan, belongs to a group of drugs called prostamides, which are synthetic structural analogs of prostaglandin. Bimatoprost, marketed by Allergan, is administered in both the ophthalmic solution and implant form. It has the ability to reduce ocular hypotension, proving effective in conditions such as ocular hypertension and glaucoma.[L6877,L6892,L6898,L12069] Bimatoprost is also used to treat eyelash hypotrichosis, or sparse eyelash growth.[L6910] It was initially approved by the FDA in 2001 for ocular hypertension and later approved for hypothrichosis in 2008, as eyelash growth became a desirable adverse effect for patients using this drug.[L4894]
Indications and Usage For the reduction of elevated intraocular pressure in patients with open angle glaucoma or ocular hypertension who are intolerant of other intraocular pressure lowering medications or insufficiently responsive (failed to achieve target IOP determined after multiple measurements over time) to another intraocular pressure lowering medication.
Marketing Status Prescription; Discontinued
ATC Code S01EE03
DrugBank ID DB00905
KEGG ID D02724
MeSH ID D000069580
PubChem ID 5311027
TTD Drug ID D0Q2XF
NDC Product Code 72266-139; 0023-3616; 82187-1001; 68083-439; 50383-912; 71052-276; 40016-005; 24002-0021; 70069-401; 0781-6206; 65129-1206; 42571-128; 62332-511; 76397-016; 73309-002; 46144-328; 54893-0009; 57741-3000; 55679-113; 82231-102; 73309-022; 0023-3205; 60505-0583; 68180-429; 50383-908; 63190-0290; 70069-402; 68245-0004; 65035-130; 72266-140; 70069-403; 62332-507; 54245-7036; 0023-9652; 68083-295; 65727-025; 72266-241; 12079-1067; 68083-296; 38779-3066; 61556-070
Synonyms Bimatoprost | Latisse | Lumigan | AGN 192024 | 192024, AGN
Chemical Information
Molecular Formula C25H37NO4
CAS Registry Number 155206-00-1
SMILES CCNC(=O)CCCC=CCC1C(CC(C1C=CC(CCC2=CC=CC=C2)O)O)O
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dyspnoea02.01.03.002; 22.02.01.004--
Enophthalmos06.09.04.0060.005596%Not Available
Erythema23.03.06.0010.027547%Not Available
Erythema of eyelid06.04.04.003; 23.03.06.0060.057677%Not Available
Extrasystoles02.03.02.0030.001291%Not Available
Eye allergy06.04.05.010; 10.01.03.0280.000861%Not Available
Eye discharge06.04.05.0010.013774%Not Available
Eye disorder06.08.03.0010.003874%Not Available
Eye haemorrhage06.07.02.001; 24.07.05.0020.002152%Not Available
Eye infection06.04.05.007; 11.01.06.0010.005165%
Eye inflammation06.04.05.0020.003013%Not Available
Eye irritation06.04.05.0030.107606%Not Available
Eye pain06.08.03.0020.024965%
Eye swelling06.08.03.0030.046916%Not Available
Eyelid infection06.04.04.013; 11.01.06.006; 23.09.04.0050.000861%Not Available
Eyelid oedema06.04.04.004; 10.01.05.001; 23.04.01.0030.027117%Not Available
Eyelid retraction06.06.04.002--Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Foreign body in eye06.11.01.005; 12.01.04.0120.001291%Not Available
Gait disturbance08.01.02.002; 17.02.05.016--
Gastrointestinal disorder07.11.01.001--Not Available
Glaucoma06.03.01.0020.001722%
Hair colour changes23.02.06.0010.001291%
Hair growth abnormal23.02.06.0060.005165%Not Available
Hair texture abnormal23.02.06.0040.001722%
Headache17.14.01.001--
Herpes zoster11.05.02.003; 23.09.03.002--
Hirsutism05.05.01.005; 23.02.04.001--
Hordeolum06.04.04.006; 11.01.06.0020.003013%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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