Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bicisate dihydrochloride
Drug ID BADD_D00272
Description Bicisate, also known as ethyl cysteinate dimer (ECD), is a N,N'-1,2-ethylene-di-yl-bis-L-cysteinate diethyl ester. It is used in conjunction with technetium Tc99m as a tracer to measure cerebral blood flow with single-photon emission computed tomography (SPECT).[A32374] The complex of bicisate and technetium Tc99m as a kit was developed by Lantheus Medcl and FDA-approved on November 23, 1994.[L2029]
Indications and Usage
Marketing Status Prescription
ATC Code V09AA02
DrugBank ID DB11164
KEGG ID D06029
MeSH ID C059659
PubChem ID 71586979
TTD Drug ID Not Available
NDC Product Code 11994-006; 58272-199; 65044-0010
Synonyms technetium Tc 99m bicisate | 99mTc ethylcysteinate dimer | 99mTc-ECD | Tc-99m-ECD | Tc-99m-bicisate | technetium Tc 99m ethyl cysteine dimer | 99mTc ethyl cysteinate dimer | Tc-99m ECD | Tc-ethyl cysteinate dimer | Neurolite | Tc-99m-L,L-ECD
Chemical Information
Molecular Formula C12H26Cl2N2O4S2
CAS Registry Number 14344-58-2
SMILES CCOC(=O)C(CS)NCCNC(CS)C(=O)OCC.Cl.Cl
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation17.02.05.012; 19.06.02.001--
Angina pectoris02.02.02.002; 24.04.04.002--
Anxiety19.06.02.002--
Apnoea22.02.01.001--
Cardiac failure02.05.01.001--
Cyanosis02.01.02.002; 22.02.02.007; 24.03.01.007--
Dizziness02.01.02.004; 17.02.05.003; 24.06.02.007--
Hallucination19.10.02.002--
Headache17.14.01.001--
Hypertension24.08.02.001--
Malaise08.01.01.003--
Nausea07.01.07.001--
Parosmia17.04.04.002; 22.04.03.007--Not Available
Rash23.03.13.001--Not Available
Seizure17.12.03.001--
Somnolence17.02.04.006; 19.02.05.003--
Syncope02.01.02.008; 17.02.04.008; 24.06.02.012--
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