Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Benzocaine
Drug ID BADD_D00237
Description Benzocaine is an ester local anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.[A231219] It is commonly used for local anesthesia in many over the counter products.[L32454,L32459,L32464] Benzocaine was first used for local anesthesia in dentistry.[A231259]
Indications and Usage Benzocaine is indicated for local anesthesia in dentistry, minor trauma, and as preparation for infiltrative anesthesia.[A231219] Benzocaine products are indicated for topical anesthesia in a wide variety of conditions including skin irritation,[L32454] oral pain,[L32459] and hemorrhoids.[L32464]
Marketing Status approved; investigational
ATC Code C05AD03; D04AB04; N01BA05; R02AD01
DrugBank ID DB01086
KEGG ID D00552
MeSH ID D001566
PubChem ID 2337
TTD Drug ID D0Q8ZX
NDC Product Code 81923-365; 81923-367; 20362-0001; 69237-001; 81999-0002; 24794-221; 24794-225; 43128-031; 43498-314; 50227-1010; 50227-1011; 53045-137; 53045-142; 54723-999; 55346-2904; 0283-0569; 0283-0871; 59779-545; 59779-830; 60913-031; 0363-1079; 0363-5061; 63736-040; 0404-0032; 67777-246; 68400-351; 68400-459; 69301-002; 69301-003; 69301-006; 69483-004; 69483-005; 69484-003; 69638-060; 69729-018; 69842-693; 70372-727; 70721-008; 70721-009; 70742-284; 71922-100; 79903-042; 80070-220; 82645-918; 49452-0971; 49964-0050; 10157-9477; 10237-200; 11822-0345; 11822-6170; 42756-1102; 42756-1103; 42756-1108; 49035-569; 50332-0050; 50486-550; 51206-202; 53045-133; 53045-146; 55346-2901; 55910-346; 0283-0293; 0283-0886; 0283-1116; 0283-1886; 58593-782; 59779-444; 63029-531; 0363-1113; 0363-1623; 0363-5820; 64522-002; 66975-350; 66975-355; 66975-357; 67239-0220; 67777-405; 68400-358; 68400-475; 68987-003; 68987-006; 68987-008; 69498-004; 69634-021; 69634-022; 70742-287; 71363-102; 71922-105; 72304-007; 82895-857; 0924-5203; 10129-071; 10202-853; 10742-8902; 69617-007; 21130-621; 24794-220; 36800-832; 37808-691; 43128-034; 50804-025; 51206-206; 61333-211; 0363-1605; 0363-6008; 63736-375; 0404-0018; 0404-0038; 66975-352; 66975-358; 68400-354; 68400-479; 69483-003; 69483-006; 69484-004; 69498-006; 69510-351; 69626-0049; 69634-020; 69634-023; 69638-062; 69638-063; 69638-064; 69745-060; 69745-063; 69842-642; 70721-003; 70721-006; 70742-180; 70742-288; 71683-005; 55346-2903; 55670-810; 55910-065; 0283-1820; 59779-743; 61010-8100; 63868-055; 67239-0223; 68400-353; 68400-456; 68987-002; 69483-009; 69638-065; 70721-001; 70769-101; 71347-102; 71347-104; 71363-104; 71922-102; 71922-103; 72304-009; 73288-006; 0699-7011; 0699-7021; 54469-0004; 11527-062; 11822-1616; 24286-1577; 24794-222; 24794-224; 25047-751; 37808-116; 41520-043; 42756-1109; 43128-033; 43498-310; 43498-313; 43498-316; 50814-038; 53045-132; 0283-0679; 0283-0920; 63240-5100; 65753-350; 66184-155; 0404-0036; 0404-0037; 67172-017; 67239-0218; 67239-0219; 68400-359; 69004-001; 69301-007; 69484-005; 69498-005; 69509-006; 69524-555; 69681-432; 69745-061; 69745-066; 70000-0553; 70000-0554; 70721-002; 70742-181; 71363-106; 72304-005; 73288-004; 81923-369; 71052-673; 11822-0615; 11822-5340; 35418-010; 42756-1104; 46414-2040; 50227-1003; 52412-350; 53045-140; 53045-144; 54723-006; 54723-009; 54723-722; 56152-1470; 59779-582; 0404-0034; 66975-351; 66975-356; 68400-461; 68987-001; 69004-005; 69301-001; 69483-001; 69483-008; 69550-324; 69634-026; 69634-027; 70742-360; 71347-100; 71363-100; 71363-103; 71363-107; 71922-104; 72304-010; 0699-7071; 10237-761; 25047-753; 25047-754; 27854-177; 36800-624; 50227-1004; 50227-1009; 53045-136; 53045-145; 54723-007; 55319-388; 55346-2902; 0283-0520; 0283-0622; 0283-0998; 0283-1016; 59779-644; 0363-0316; 63736-050; 63824-259; 64522-004; 65923-094; 66184-161; 0404-0035; 66975-353; 66975-354; 67659-410; 68400-323; 68400-352; 68400-458; 68400-508; 69004-004; 69483-002; 69483-007; 69484-002; 69509-001; 69509-003; 69509-005; 69510-352; 69510-355; 69745-062; 69745-064; 69842-660; 70721-004; 70721-007; 70742-282; 70742-286; 71347-103; 71687-1053; 71922-101; 72304-008; 64090-0010; 11822-0043; 11822-0316; 25047-752; 25047-755; 36800-443; 36800-512; 42961-401; 43128-032; 43498-311; 50227-1001; 50227-1007; 53045-131; 53045-134; 53045-135
UNII U3RSY48JW5
Synonyms Benzocaine | 4-Aminobenzoic Acid Ethyl Ester | Bensokain | Ethyl Aminobenzoate | Anaesthesin | Anesthesin | Benzocaine Hydrobromide | Hydrobromide, Benzocaine | Benzocaine Hydrochloride | Hydrochloride, Benzocaine | Benzocaine Acetate | Acetate, Benzocaine | Benzocaine Methanesulfonate | Methanesulfonate, Benzocaine | Ethoform | Americaine | Benzocaine Formate | Formate, Benzocaine
Chemical Information
Molecular Formula C9H11NO2
CAS Registry Number 94-09-7
SMILES CCOC(=O)C1=CC=C(C=C1)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cyanosis02.11.04.004; 22.02.02.007; 23.06.04.005; 24.03.01.007--
Dermatitis23.03.04.002---
Dermatitis contact10.01.01.003; 12.03.01.040; 23.03.04.004---
Dyspnoea02.11.05.003; 22.02.01.004--
Erythema23.03.06.001---
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Methaemoglobinaemia01.05.01.002--
Nausea07.01.07.001--
Oedema08.01.07.006; 14.05.06.010---
Oral discomfort07.05.05.001---
Oral pain07.05.05.034--
Pain08.01.08.004--
Pruritus23.03.12.001--
Pyrexia08.05.02.003--
Rash23.03.13.001---
Respiratory distress22.02.01.012---
Skin irritation23.03.04.009---
Swelling08.01.03.015---
Tenderness08.01.08.005---
Urticaria10.01.06.001; 23.04.02.001--
Vomiting07.01.07.003--
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