Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bendroflumethiazide
Drug ID BADD_D00232
Description A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)
Indications and Usage For the treatment of high blood pressure and management of edema related to heart failure.
Marketing Status approved
ATC Code C03AA01
DrugBank ID DB00436
KEGG ID D00650
MeSH ID D001539
PubChem ID 2315
TTD Drug ID D02PAH
NDC Product Code 69988-0028; 53747-004
UNII 5Q52X6ICJI
Synonyms Bendroflumethiazide | Bendrofluazide | Benzide | Benzide-M | Benzide M | Berkozide | Urizid | Esberizid | Naturetin | Neo-NaClex | Neo NaClex | Aprinox | Centyl | Pluryl | Naturine
Chemical Information
Molecular Formula C15H14F3N3O4S2
CAS Registry Number 73-48-3
SMILES C1=CC=C(C=C1)CC2NC3=C(C=C(C(=C3)C(F)(F)F)S(=O)(=O)N)S(=O)(=O)N2
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Muscle spasms15.05.03.004--
Nausea07.01.07.001--
Orthostatic hypotension17.05.01.020; 24.06.03.004---
Pancreatitis07.18.01.001--
Paraesthesia17.02.06.005; 23.03.03.094--
Photosensitivity reaction23.03.09.003--
Pneumonitis22.01.01.006--
Polyuria20.02.03.002---
Pruritus23.03.12.001--
Purpura01.01.04.003; 23.06.01.004; 24.07.06.005--
Pyrexia08.05.02.003--
Rash23.03.13.001---
Restlessness17.02.05.021; 19.11.02.002--
Sialoadenitis07.06.04.002; 11.01.04.002--
Thirst08.01.09.021; 14.03.02.007---
Thrombocytopenia01.08.01.002---
Urticaria10.01.06.001; 23.04.02.001--
Vascular purpura01.01.04.007; 23.06.01.008; 24.07.06.011---
Vasculitis10.02.02.006; 24.12.04.027--
Vasculitis necrotising10.02.02.008; 24.12.04.029---
Vertigo04.04.01.003; 17.02.12.002--
Vision blurred06.02.06.007; 17.17.01.010--
Vomiting07.01.07.003--
Xanthopsia06.02.05.002---
Hypocalciuria14.04.01.014; 20.02.01.030---
Epigastric discomfort07.01.02.004---
Urine output increased13.13.03.002---
Decreased appetite08.01.09.028; 14.03.01.005--
Erectile dysfunction19.08.04.001; 21.03.01.007--
Blood disorder01.05.01.004---
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