Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Balsalazide
Drug ID BADD_D00210
Description Balsalazide is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease. It is sold under the name "Colazal" in the US and "Colazide" in the UK. The chemical name is (E)-5-[[-4-(2-carboxyethyl) aminocarbonyl] phenyl]azo] -2-hydroxybenzoic acid. It is usually administered as the disodium salt. Balsalazide works by deliverying mesalazine to the large intestine to act directly on ulcerative colitis. Mesalazine is also known as 5-aminosalicylic acid, or 5-ASA.
Indications and Usage For the treatment of mildly to moderately active ulcerative colitis.
Marketing Status approved; investigational
ATC Code A07EC04
DrugBank ID DB01014
KEGG ID D07488
MeSH ID C038637
PubChem ID 54585
TTD Drug ID D0A6KR
NDC Product Code Not Available
UNII P80AL8J7ZP
Synonyms balsalazide | 5-(carboxyethylcarbamoyl-4-phenylazo)salicylic acid | BX 661A | BX661A | Colazide | balsalazine | balsalazide disodium | Colazal
Chemical Information
Molecular Formula C17H15N3O6
CAS Registry Number 80573-04-2
SMILES C1=CC(=CC=C1C(=O)NCCC(=O)O)N=NC2=CC(=C(C=C2)O)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pancreatitis07.18.01.001--
Pericarditis02.06.02.001--
Pharyngitis07.05.07.004; 11.01.13.003; 22.07.03.004--
Pleural effusion22.05.02.002--
Pneumonia11.01.09.003; 22.07.01.003---
Pruritus23.03.12.001--
Rash23.03.13.001---
Rectal haemorrhage07.12.03.001; 24.07.02.018--
Renal failure20.01.03.005---
Rhinitis11.01.13.004; 22.07.03.006--
Stomatitis07.05.06.005--
Swelling08.01.03.015---
Tachycardia02.03.02.007---
Upper respiratory tract infection11.01.13.009; 22.07.03.011--
Urinary tract infection11.01.14.004; 20.08.02.001--
Vasculitis10.02.02.006; 24.12.04.027--
Vomiting07.01.07.003--
Tubulointerstitial nephritis20.05.02.002---
Musculoskeletal discomfort15.03.04.001---
Hepatic enzyme increased13.03.04.028---
Connective tissue disorder10.04.04.026; 15.06.01.006---
Infestation11.09.01.001; 23.11.01.002---
Mediastinal disorder22.09.03.001---
Decreased appetite08.01.09.028; 14.03.01.005--
Ill-defined disorder08.01.03.049---
Hepatobiliary disease09.01.08.003---
Respiratory tract infection11.01.08.017; 22.07.07.001---
Liver injury09.01.07.022; 12.01.17.012---
Liver function test increased13.03.04.031---
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ADReCS-Target
Drug Name ADR Term Target
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