Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Aztreonam
Drug ID BADD_D00206
Description A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.
Indications and Usage For the treatment of the following infections caused by susceptible gram-negative microorganisms: urinary tract infections, lower respiratory tract infections, septicemia, skin and skin-structure infections, intra-abdominal infections, and gynecologic infections.
Marketing Status approved
ATC Code J01DF01
DrugBank ID DB00355
KEGG ID D00240
MeSH ID D001398
PubChem ID 2274
TTD Drug ID D0F2XV
NDC Product Code 24525-0025; 13538-001; 0409-0830; 54087-160; 63323-401; 63323-402; 52952-001; 0003-2570; 0003-2560; 73301-008; 13538-008; 61958-0901; 0409-0829; 13538-009
UNII G2B4VE5GH8
Synonyms Aztreonam | Az-threonam | Az threonam | Azthreonam | SQ-26,776 | SQ 26,776 | SQ26,776 | Urobactam | Azactam
Chemical Information
Molecular Formula C13H17N5O8S2
CAS Registry Number 78110-38-0
SMILES CC1C(C(=O)N1S(=O)(=O)O)NC(=O)C(=NOC(C)(C)C(=O)O)C2=CSC(=N2)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Local reaction08.01.03.012---
Malaise08.01.01.003--
Mouth ulceration07.05.06.004---
Myalgia15.05.02.001--
Nasal congestion22.04.04.001--
Nausea07.01.07.001--
Neutropenia01.02.03.004---
Pain08.01.08.004--
Pancytopenia01.03.03.003---
Paraesthesia17.02.06.005; 23.03.03.094--
Petechiae01.01.03.002; 23.06.01.003; 24.07.06.004---
Phlebitis12.02.01.002; 24.12.03.004--
Pruritus23.03.12.0010.000049%
Pseudomembranous colitis07.19.01.003; 11.02.02.002---
Purpura01.01.04.003; 23.06.01.004; 24.07.06.005--
Pyrexia08.05.02.0030.000049%
Rash23.03.13.0010.000097%-
Renal failure20.01.03.0050.000073%-
Seizure17.12.03.001--
Sneezing22.12.03.024--
Stomatitis07.05.06.005--
Swelling08.01.03.015---
Tachycardia02.03.02.0070.000049%-
Thrombocytopenia01.08.01.0020.000097%-
Thrombocytosis01.08.02.001---
Thrombophlebitis24.01.02.001---
Tinnitus04.04.01.002; 17.04.07.004--
Toxic epidermal necrolysis10.01.01.006; 11.07.01.006; 12.03.01.015; 23.03.01.008--
Urticaria10.01.06.001; 23.04.02.0010.000131%
Vaginal infection11.01.10.002; 21.14.02.002--
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