| Drug Name |
Azelastine hydrochloride |
| Drug ID |
BADD_D00199 |
| Description |
Azelastine, a phthalazine derivative, is an antihistamine available as an intranasal spray for the treatment of allergic and vasomotor rhinitis and as an ophthalmic solution for the treatment of allergic conjunctivitis.[L8240,L8270] It is a racemic mixture, though there is no noted difference in pharmacologic activity between enantiomers, and was first granted FDA approval in 1996.[L8240,L8270] Azelastine is also available in combination with fluticasone propionate as a nasal spray marketed under the trade name Dymista™, which is indicated for the symptomatic treatment of seasonal allergic rhinitis in patients 6 years of age and older.[L8309] |
| Indications and Usage |
Intranasal azelastine is indicated for the symptomatic treatment of seasonal allergic rhinitis in patients 5 years and older and for the symptomatic treatment of vasomotor rhinitis in patients 12 years and older.[L8240] Ophthalmic azelastine solution is indicated for the treatment of itchy eyes associated with allergic conjunctivitis.[L8270]
As a 0.15% nasal spray, azelastine hydrochloride is also indicated for over-the-counter treatment of allergies in patients aged six years and older.[L34640] |
| Marketing Status |
approved |
| ATC Code |
S01GX07; R06AX19; R01AC03 |
| DrugBank ID |
DB00972
|
| KEGG ID |
D00659
|
| MeSH ID |
C020976
|
| PubChem ID |
54360
|
| TTD Drug ID |
D00JVR
|
| NDC Product Code |
51927-0302; 53002-2279; 53002-5279; 50090-2330; 70069-091; 72266-141; 49274-1101; 55486-1575; 53002-1803; 51927-5005; 57572-0713; 47335-938; 50383-942; 59651-215; 65841-164; 59651-214; 68382-415; 0054-0293; 53002-1279; 68083-287; 14501-0048; 47335-779; 60505-0578; 60505-0833; 71205-449; 51991-814; 60505-0848; 61314-308; 70771-1313; 49076-7601; 54752-0008; 60656-1839 |
| UNII |
0L591QR10I
|
| Synonyms |
azelastine | 4-(p-chlorobenzyl)-2-(N-methylperhydroazepinyl-(4))-1-(2H)-phthalazinone | Allergodil | Astelin | azelastine hydrochloride | 4-((4-chlorophenyl)methyl)-2- (hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)- phthalazinone HCl | Corifina | Loxin | Vividrin akut Azelastin | Optivar | Rhinolast | Optilast | Afluon | A 5610 | A-5610 | Azeptin |
