ADReCS

Pharmaceutical Information

Drug Name	Azathioprine
Drug ID	BADD_D00195
Description	Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection.[L11214] Azathiprine was granted FDA approval on 20 March 1968.[L11214]
Indications and Usage	Anstey A, Lear JT: Azathioprine: clinical pharmacology and current indications in autoimmune disorders. BioDrugs. 1998 Jan;9(1):33-47.
Marketing Status	Prescription; Discontinued
ATC Code	L04AX01
DrugBank ID	DB00993
KEGG ID	D00238
MeSH ID	D001379
PubChem ID	2265
TTD Drug ID	D07QCE
NDC Product Code	72789-129; 51407-182; 46014-1110; 62991-2189; 12780-0300; 51927-2258; 48954-909; 51552-0779; 15308-0732; 42973-143; 68382-120; 38779-0312; 68382-119; 67877-492; 70771-1139; 65649-241; 68382-118; 67877-494; 54766-590; 68462-502; 0378-1005; 71610-124; 60219-2036; 70771-1140; 51927-0071; 65841-602; 68382-003; 71610-306; 42291-071; 60219-2037; 68084-229; 60219-1076; 70771-1141; 49452-0783; 65649-231; 67877-495; 67877-493; 66122-0009
Synonyms	Azathioprine \| Azothioprine \| Imurel \| Imuran \| Immuran \| Azathioprine Sodium \| Sodium, Azathioprine \| Azathioprine Sodium Salt \| Azathioprine Sulfate

Chemical Information

Molecular Formula	C9H7N7O2S
CAS Registry Number	446-86-6
SMILES	CN1C=NC(=C1SC2=NC=NC3=C2NC=N3)[N+](=O)[O-]
Chemical Structure

ADRs Induced by Drug

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Cardiovascular disorder	02.01.01.001; 24.03.02.009	-	-	Not Available
Cataract	06.06.01.001	-	-
Cellulitis	11.02.01.001; 23.09.01.001	0.004308%		Not Available
Cerebral infarction	17.08.01.004; 24.04.06.002	-	-	Not Available
Cerebrovascular accident	17.08.01.007; 24.03.05.001	-	-
Cervical dysplasia	21.06.01.002	0.003590%		Not Available
Chest discomfort	02.02.02.009; 08.01.08.019; 22.02.08.001	-	-	Not Available
Chest pain	02.02.02.011; 08.01.08.002; 22.02.08.003	-	-	Not Available
Chest X-ray abnormal	13.19.02.001	0.001436%		Not Available
Chills	08.01.09.001; 15.05.03.016	0.015796%
Cholangitis sclerosing	09.02.01.003; 10.04.09.002	0.002154%		Not Available
Cholecystitis	09.03.01.001	0.002154%
Cholelithiasis	09.03.01.002	0.002154%		Not Available
Cholestasis	09.01.01.001	0.005026%		Not Available
Chromaturia	20.02.01.002	0.002154%
Chronic lymphocytic leukaemia	01.10.06.001; 16.01.06.001	0.000937%		Not Available
Chronic myeloid leukaemia	01.10.07.001; 16.01.07.001	0.000375%		Not Available
Clostridium difficile colitis	07.19.01.004; 11.02.02.004	0.001436%		Not Available
Coagulopathy	01.01.02.001	0.007898%		Not Available
Colitis	07.08.01.001	0.021540%
Colitis ulcerative	07.08.01.005; 10.02.01.004	0.030874%		Not Available
Colon cancer	07.21.01.001; 16.13.01.001	0.000562%		Not Available
Confusional state	17.02.03.005; 19.13.01.001	-	-
Conjunctivitis	06.04.01.002; 11.01.06.012	0.002154%
Constipation	07.02.02.001	-	-
Cough	22.02.03.001	0.017950%
Crohn's disease	07.08.01.015; 10.02.01.005	0.127804%		Not Available
Crying	08.01.03.005; 12.02.11.001; 17.02.05.013; 19.04.02.002	-	-	Not Available
Cryptococcosis	11.03.04.001	0.001436%		Not Available
Cushing's syndrome	05.01.01.001; 14.11.01.007; 19.07.03.002; 24.08.04.001	0.001436%		Not Available

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