Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Atovaquone
Drug ID BADD_D00186
Description Atovaquone is a hydroxynaphthoquinone, or an analog of ubiquinone, that has antimicrobial and antipneumocystis activity. It is being used in antimalarial protocols.
Indications and Usage For the treatment or prevention of Pneumocystis carinii pneumonia in patients who are intolerant to trimethoprim-sulfamethoxazole (TMP-SMX). Also indicated for the acute oral treatment of mild to moderate PCP in patients who are intolerant to TMP-SMX.
Marketing Status approved
ATC Code P01AX06
DrugBank ID DB01117
KEGG ID D00236
MeSH ID D053626
PubChem ID 74989
TTD Drug ID D06ZEE
NDC Product Code 0904-7064; 62147-0058; 0121-1796; 68462-421; 58159-048; 65977-0034; 51552-1629; 0173-0547; 62135-528; 65162-693; 69452-252; 70748-299; 65015-734; 59651-090; 63827-1005; 71052-261; 16714-900; 31722-629; 51407-642; 10702-223; 0121-0898; 60687-534; 66039-840; 0173-0665; 62147-0057; 66039-928; 66689-062; 62331-059; 50268-086
UNII Y883P1Z2LT
Synonyms Atovaquone | 2-(4-(4'-chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone | 2-(trans-4-(4-chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone | Wellvone | Mepron | 566C | compound 566 | 566C80 | hydroxynaphthoquinone 566C80 | 566C80 hydroxynaphthoquinone | hydroxynaphthoquinone, 566C80
Chemical Information
Molecular Formula C22H19ClO3
CAS Registry Number 94015-53-9
SMILES C1CC(CCC1C2=CC=C(C=C2)Cl)C3=C(C4=CC=CC=C4C(=O)C3=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Psychotic disorder19.03.01.0020.000142%
Hepatobiliary disease09.01.08.003---
Renal impairment20.01.03.010---
Oropharyngeal pain07.05.05.004; 22.12.03.0160.000142%
Acute kidney injury20.01.03.0160.000283%
Drug-induced liver injury09.01.07.023; 12.03.01.0440.000213%-
Drug reaction with eosinophilia and systemic symptoms10.01.01.021; 12.03.01.064; 23.03.05.0050.000354%-
Multiple organ dysfunction syndrome08.01.03.0570.000213%
Cornea verticillata06.06.03.016---
Illness08.01.03.0910.000142%-
Immune thrombocytopenia01.08.01.013; 10.02.01.0830.000142%-
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