| Drug Name |
Atezolizumab |
| Drug ID |
BADD_D00179 |
| Description |
Atezolizumab is a humanized monoclonal antibody used to prevent the interaction of PD-L1 and PD-1, removing inhibition of immune responses seen in some cancers.[A18493,L7489] This medication is reserved for patients whose tumors express PD-L1, cannot receive platinum based chemotherapy, or whose tumors do not respond to platinum based chemotherapy.[L7489] Atezolizumab was granted FDA approval on 18 October 2016.[L7489] |
| Indications and Usage |
Atezolizumab is indicated to treat locally or advanced metastatic urothelial carcinoma in patients ineligible for cicplatin-containing chemotherapy with tumors expressing PD-L1, in patients ineligible for cisplatin-containing chemotherapy irrespective of PD-L1, have disease progression following platinum containing chemotherapy, or have disease progression within 12 months of neoadjuvant or adjuvant chemotherapy.[L7489]
Atezolizumab is also indicated first line for non small cell lung cancer in combination with bevacizumab, paclitaxel, and carboplatin with no EGFR or ALK genomic abnormalities.[L7489] It can be used in patients with disease progression during or after platinum containing chemotherapy even if they have EGFR and ALK abnormalities.[L7489]
Atezolizumab is indicated in combination with paclitaxel protein-bound to treat locally advanced or metastatic triple negative breast cancer expressing PD-L1.[L7489]
Finally, atezolizumab is indicated in combination with carboplatin and etoposide as first line treatment for extensive stage small cell lung cancer.[L7489] |
| Marketing Status |
approved; investigational |
| ATC Code |
L01FF05 |
| DrugBank ID |
DB11595
|
| KEGG ID |
D10773
|
| MeSH ID |
C000594389
|
| PubChem ID |
Not Available
|
| TTD Drug ID |
Not Available
|
| NDC Product Code |
12806-0917; 50242-918; 50242-917 |
| UNII |
52CMI0WC3Y
|
| Synonyms |
atezolizumab | anti-PDL1 | immunoglobulin G1, anti-(human CD antigen CD274) (human monoclonal MDPL3280a heavy chain), disulfide with human monoclonal MDPL3280a kappa-chain, dimer | MPDL3280A | MPDL-3280A | Tecentriq | RG7446 | RG-7446 |
