Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Arformoterol
Drug ID BADD_D00159
Description Arformoterol is a bronchodilator. It works by relaxing muscles in the airways to improve breathing. Arformoterol inhalation is used to prevent bronchoconstriction in people with chronic obstructive pulmonary disease, including chronic bronchitis and emphysema. The use of arformoterol is pending revision due to safety concerns in regards to an increased risk of severe exacerbation of asthma symptoms, leading to hospitalization as well as death in some patients using long acting beta agonists for the treatment of asthma.
Indications and Usage A bronchodilator used for the long term, symptomatic treatment of reversible bronchoconstriction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema.
Marketing Status approved; investigational
ATC Code R03CC15; R03AC13
DrugBank ID DB01274
KEGG ID D07463
MeSH ID D000068759
PubChem ID 3083544
TTD Drug ID D0D1DI
NDC Product Code Not Available
UNII F91H02EBWT
Synonyms Formoterol Fumarate | Formoterol Fumarate, ((R*,R*)-(+-))-isomer | 3-Formylamino-4-hydroxy-alpha-(N-1-methyl-2-p-methoxyphenethylaminomethyl)benzyl alcohol.hemifumarate | BD 40A | Formoterol | Eformoterol | Oxis | Arformoterol | Formoterol, ((R*,R*)-(+-))-isomer | Foradil
Chemical Information
Molecular Formula C19H24N2O4
CAS Registry Number 67346-49-0
SMILES CC(CC1=CC=C(C=C1)OC)NCC(C2=CC(=C(C=C2)O)NC=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Metabolic acidosis14.01.01.003---
Muscle spasms15.05.03.004--
Myocardial infarction02.02.02.007; 24.04.04.009--
Nasopharyngitis11.01.13.002; 22.07.03.002---
Nausea07.01.07.001--
Neoplasm16.16.02.001---
Nephrolithiasis20.04.01.002--
Nervousness19.06.02.003---
Nocturia20.02.03.001---
Oedema08.01.07.006; 14.05.06.010---
Oedema peripheral02.05.04.007; 08.01.07.007; 14.05.06.011--
Oral candidiasis07.05.07.001; 11.03.03.004---
Pain08.01.08.004--
Palpitations02.11.04.012--
Paralysis17.01.04.004---
Pelvic pain07.01.06.012; 20.02.03.007; 21.10.01.001--
Pyuria11.01.08.043; 20.08.02.016---
Rash23.03.13.001---
Rectal haemorrhage07.12.03.001; 24.07.02.018--
Retroperitoneal haemorrhage07.07.02.002; 12.01.17.018; 24.07.01.017--
Rheumatoid arthritis10.04.06.001; 15.01.03.001---
Sinusitis11.01.13.005; 22.07.03.007--
Skin discolouration23.03.03.005---
Skin hypertrophy23.01.04.002---
Somnolence17.02.04.006; 19.02.05.003--
Supraventricular tachycardia02.03.03.012--
Tachycardia02.03.02.007---
Tendinous contracture15.07.01.001---
Tension19.06.02.005---
Tooth abscess07.09.01.003; 11.01.04.003---
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