Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Apraclonidine
Drug ID BADD_D00154
Description Apraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist.
Indications and Usage For prevention or reduction of intraoperative and postoperative increases in intraocular pressure (IOP) before and after ocular laser surgery when used prophylactically. Also used as a short-term adjunctive therapy in patients with open-angle glaucoma who are on maximally tolerated medical therapy requiring additional IOP reduction.
Marketing Status approved
ATC Code S01EA03
DrugBank ID DB00964
KEGG ID D07461
MeSH ID C016986
PubChem ID 2216
TTD Drug ID D0MT0M
NDC Product Code 61314-665
UNII 843CEN85DI
Synonyms apraclonidine | 4-aminoclonidine | para-aminoclonidine | 2-(4-amino-2,6-dichloro)phenyliminoimidazolidine | p-aminoclonidine | apraclonidine hydrochloride | Iopidine | Iopimax | ALO 2145 | ALO-2145
Chemical Information
Molecular Formula C9H10Cl2N4
CAS Registry Number 66711-21-5
SMILES C1CN=C(N1)NC2=C(C=C(C=C2Cl)N)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Oedema08.01.07.006; 14.05.06.010---
Oedema peripheral02.05.04.007; 08.01.07.007; 14.05.06.011--
Pain08.01.08.004--
Pallor08.01.03.032; 23.03.03.031; 24.03.04.001---
Palpitations02.11.04.012--
Paraesthesia17.02.06.005; 23.03.03.094--
Parosmia17.04.04.002; 22.04.03.007---
Pharyngitis07.05.07.004; 11.01.13.003; 22.07.03.004--
Photophobia06.01.01.004; 17.17.02.006--
Presyncope02.11.04.013; 17.02.05.009; 24.06.02.010--
Pruritus23.03.12.001--
Rhinitis11.01.13.004; 22.07.03.006--
Rhinorrhoea22.12.03.021--
Scab23.03.03.004---
Skin disorder23.03.03.007---
Somnolence17.02.04.006; 19.02.05.003--
Syncope02.11.04.015; 17.02.04.008; 24.06.02.012--
Tension19.06.02.005---
Throat irritation07.05.05.037; 22.12.03.029---
Vision blurred06.02.06.007; 17.17.01.010--
Visual acuity reduced06.02.10.012; 17.17.01.011--
Visual impairment06.02.10.013---
Vital dye staining cornea present13.07.04.010---
Vomiting07.01.07.003--
Foreign body sensation in eyes06.01.01.006---
Eyelid margin crusting06.04.04.005; 23.03.03.029---
Eye oedema06.08.03.013---
Eye pruritus06.04.05.006---
Ocular discomfort06.08.03.008---
Musculoskeletal discomfort15.03.04.001---
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