Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apomorphine
Drug ID BADD_D00152
Description Apomorphine is a non-ergoline dopamine D2 agonist indicated to treat hypomobility associated with Parkinson's. It was first synthesized in 1845 and first used in Parkinson's disease in 1884.[A203618] Apomorphine has also been investigated as an emetic, a sedative, a treatment for alcoholism, and a treatment of other movement disorders.[A203597,A203618] Apomorphine was granted FDA approval on 20 April 2004.[L13919]
Indications and Usage Apomorphine is indicated to treat acute, intermittent treatment of hypomobility, off episodes associated with advanced Parkinson's disease.[L13919,L13922]
Marketing Status approved; investigational
ATC Code G04BE07; N04BC07
DrugBank ID DB00714
KEGG ID D07460
MeSH ID D001058
PubChem ID 6005
TTD Drug ID D0H6QU
NDC Product Code Not Available
UNII N21FAR7B4S
Synonyms Apomorphine | Apomorphine Hydrochloride, Anhydrous | Apomorphine Hydrochloride Anhydrous | Apomorphine Hydrochloride | Apomorphin-Teclapharm | Apomorphin Teclapharm | Apomorphine Hydrochloride, Hemihydrate | Apokinon | Apomorphine Chloride | Britaject
Chemical Information
Molecular Formula C17H17NO2
CAS Registry Number 58-00-4
SMILES CN1CCC2=C3C1CC4=C(C3=CC=C2)C(=C(C=C4)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pruritus23.03.12.001--
Pyrexia08.05.02.0030.000636%
Respiratory disorder22.02.07.0020.000182%-
Restlessness17.02.05.021; 19.11.02.0020.000618%
Rhinorrhoea22.12.03.0210.001546%
Shock24.06.02.002---
Skin necrosis23.03.03.0110.000455%-
Skin reaction10.01.03.019; 23.03.03.0130.000182%-
Skin ulcer23.07.03.003; 24.04.03.0070.000182%
Sleep disorder19.02.04.0010.000491%-
Sneezing22.12.03.0240.000618%
Somnolence17.02.04.006; 19.02.05.0030.004964%
Swelling08.01.03.015---
Syncope02.11.04.015; 17.02.04.008; 24.06.02.0120.000491%
Thinking abnormal17.02.05.023; 19.10.03.0010.000618%-
Tremor17.01.06.0020.001509%
Unresponsive to stimuli17.02.05.0310.000182%-
Urinary tract infection11.01.14.004; 20.08.02.001--
Vision blurred06.02.06.007; 17.17.01.0100.000618%
Vomiting07.01.07.0030.005364%
Yawning22.12.03.0370.001509%-
Peripheral swelling02.05.04.015; 08.01.03.0530.000927%-
General physical health deterioration08.01.03.0180.000455%-
Contusion12.01.06.001; 15.03.05.007; 23.03.11.002; 24.07.06.001--
Musculoskeletal discomfort15.03.04.001---
Nodule08.03.05.0020.000909%-
Injection site nodule08.02.03.034; 12.07.03.034; 23.07.04.0090.001346%-
Disturbance in sexual arousal19.08.04.003---
Hot flush08.01.03.027; 21.02.02.001; 24.03.01.0050.000618%
Inflammation08.01.05.007; 10.02.01.0890.000182%-
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ADReCS-Target
Drug Name ADR Term Target
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