Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apomorphine
Drug ID BADD_D00152
Description Apomorphine is a non-ergoline dopamine D2 agonist indicated to treat hypomobility associated with Parkinson's. It was first synthesized in 1845 and first used in Parkinson's disease in 1884.[A203618] Apomorphine has also been investigated as an emetic, a sedative, a treatment for alcoholism, and a treatment of other movement disorders.[A203597,A203618] Apomorphine was granted FDA approval on 20 April 2004.[L13919]
Indications and Usage Apomorphine is indicated to treat acute, intermittent treatment of hypomobility, off episodes associated with advanced Parkinson's disease.[L13919,L13922]
Marketing Status approved; investigational
ATC Code G04BE07; N04BC07
DrugBank ID DB00714
KEGG ID D07460
MeSH ID D001058
PubChem ID 6005
TTD Drug ID D0H6QU
NDC Product Code Not Available
UNII N21FAR7B4S
Synonyms Apomorphine | Apomorphine Hydrochloride, Anhydrous | Apomorphine Hydrochloride Anhydrous | Apomorphine Hydrochloride | Apomorphin-Teclapharm | Apomorphin Teclapharm | Apomorphine Hydrochloride, Hemihydrate | Apokinon | Apomorphine Chloride | Britaject
Chemical Information
Molecular Formula C17H17NO2
CAS Registry Number 58-00-4
SMILES CN1CCC2=C3C1CC4=C(C3=CC=C2)C(=C(C=C4)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Injection site inflammation08.02.03.008; 12.07.03.0090.000273%-
Injection site necrosis08.02.03.020; 12.07.03.0200.000546%-
Injection site pain08.02.03.010; 12.07.03.0110.000927%-
Injection site pruritus08.02.03.013; 12.07.03.014; 23.03.12.0070.002164%-
Injection site rash08.02.03.032; 12.07.03.032; 23.03.13.0100.000618%-
Injection site reaction08.02.03.014; 12.07.03.0150.000618%
Insomnia17.15.03.002; 19.02.01.0020.001018%
Intestinal obstruction07.13.01.0020.000455%-
Jaundice01.06.04.004; 09.01.01.004; 23.03.03.0300.000273%-
Libido increased19.08.03.002; 21.03.02.007--
Loss of consciousness17.02.04.0040.001109%-
Malaise08.01.01.0030.001418%
Mania19.16.02.0020.000582%
Mood altered19.04.02.0070.000400%-
Muscle rigidity15.05.04.001; 17.05.02.0050.000182%-
Myocardial infarction02.02.02.007; 24.04.04.0090.000273%
Nasopharyngitis11.01.13.002; 22.07.03.002---
Nausea07.01.07.0010.008183%
Oedema08.01.07.006; 14.05.06.010---
Oedema peripheral02.05.04.007; 08.01.07.007; 14.05.06.0110.000400%
On and off phenomenon17.01.05.0040.004019%-
Orthostatic hypotension17.05.01.020; 24.06.03.004---
Pain in extremity15.03.04.0100.000800%
Pallor08.01.03.032; 23.03.03.031; 24.03.04.001---
Palpitations02.11.04.0120.000400%
Panic attack19.06.04.0010.000400%-
Panniculitis10.01.03.024; 23.07.02.0020.000636%-
Paranoia19.05.01.0050.000618%-
Pneumonia11.01.09.003; 22.07.01.003---
Priapism21.03.01.005; 24.04.12.007---
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ADReCS-Target
Drug Name ADR Term Target
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