Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. It has also been used to lower the risk of developing venous thrombosis post-orthopedic surgical procedures.
Marketing Status Prescription
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 65129-1344; 55111-980; 50193-0893; 63629-8432; 16436-0113; 70366-001; 46708-908; 52048-0420; 63850-8085; 42816-0893; 14445-150; 59651-051; 53747-062; 65015-897; 55154-0613; 66174-0091; 76397-007; 75945-060; 24196-190; 15308-1221; 12783-0894; 66651-921; 63415-0520; 70518-1861; 66039-925; 65372-1196; 55154-0612; 12783-0893; 69989-0006; 76397-010; 42765-025; 76072-1017; 14501-0089; 67835-0015; 69037-0023; 50090-1437; 0003-0894; 58623-0137; 0003-3764; 42816-0894; 67296-1673; 58032-2028; 50090-1436; 65727-081; 14445-014; 63629-7747; 14445-149
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Meniscus injury12.04.03.008; 15.07.03.006--Not Available
Eye contusion06.11.01.011; 12.01.04.024; 24.07.06.0220.000265%Not Available
Ophthalmic vein thrombosis06.07.02.007; 24.01.05.0110.000265%Not Available
Gastrointestinal polyp haemorrhage07.20.01.011; 16.05.03.003; 24.07.02.0460.001192%Not Available
Traumatic haemothorax12.01.03.010; 22.05.02.008; 24.07.01.0850.000795%Not Available
Spontaneous haemorrhage01.01.03.007; 24.07.01.0810.001325%Not Available
Oral mucosa haematoma07.05.02.003; 24.07.02.0530.000397%Not Available
Internal haemorrhage24.07.01.0720.012055%Not Available
Cerebral ventricular rupture12.01.10.015; 17.11.01.0140.000415%Not Available
Gluten sensitivity07.17.01.009; 10.01.01.031; 14.02.01.0080.000265%Not Available
Lacunar stroke17.08.01.054; 24.04.06.0370.000104%Not Available
Vein rupture12.01.11.011; 24.03.02.0320.000662%Not Available
End stage renal disease20.01.03.0190.001060%Not Available
Intracranial mass17.11.01.0170.000530%Not Available
Anti factor X activity increased13.01.02.0440.000530%Not Available
Anti factor X activity decreased13.01.02.0430.000397%Not Available
Tongue discomfort07.14.02.0190.000265%Not Available
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