Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is indicated for reducing the risk of stroke and systemic embolism in patients who have nonvalvular atrial fibrillation, prophylaxis of deep vein thrombosis(DVT) leading to pulmonary embolism(PE) in patients after a hip or knee replacement surgery, and treatment of DVT and PE to reduce the risk of recurrence[Label,A177565,A6897].
Marketing Status approved
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 52048-0420; 69037-0023; 76397-007; 15308-1221; 24196-190; 58032-2028; 66174-0091; 50193-0893; 65372-1196; 65727-081; 0003-3764; 55154-0612; 59651-051; 70366-001; 14445-149; 12783-0893; 12783-0894; 17381-026; 42765-025; 42816-0894; 58623-0137; 63850-8085; 65129-1344; 66039-925; 66651-921; 69989-0006; 63629-7747; 12658-0440; 53869-0893; 73377-191; 55154-0613; 70518-1861; 71610-662; 67835-0015; 75945-060; 76397-010; 50090-6454; 82982-054; 14501-0089; 16436-0113; 65129-1465; 63629-8432; 14445-014; 53747-062; 53869-0894; 63415-0520; 65015-897; 76072-1017; 14445-150; 42816-0893; 0003-0894; 55111-980; 50090-6451
UNII 3Z9Y7UWC1J
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Device related thrombosis08.07.05.001; 24.01.01.0270.000108%-
Gingival discomfort07.09.13.003---
Adenocarcinoma gastric07.21.02.002; 16.13.03.0020.000043%-
Adenocarcinoma of colon07.21.01.008; 16.13.01.0100.000065%-
Anaemia of chronic disease01.03.04.0020.000043%-
Antiphospholipid syndrome01.01.02.016; 10.04.01.009; 18.02.04.002; 24.01.01.0290.000716%-
Apallic syndrome17.02.04.0180.000065%-
Arterial rupture12.01.11.010; 24.03.02.0270.000130%-
Bleeding varicose vein24.10.04.0020.000108%-
Blood blister12.01.06.013; 23.03.01.0280.000508%-
Brain neoplasm malignant16.30.04.002; 17.20.04.0020.000065%-
Bronchial carcinoma16.19.02.004; 22.08.01.0150.000087%-
Cardiac aneurysm02.04.02.030; 24.02.02.0040.000065%-
Cardiac failure chronic02.05.01.0090.000239%-
Cerebellar haemorrhage17.08.01.046; 24.07.04.0230.000803%-
Cerebral artery thrombosis17.08.01.026; 24.01.04.0080.000087%-
Cervical cord compression17.10.02.0020.000043%-
Cervical spinal stenosis15.10.04.006; 17.10.02.0060.000043%-
Choroidal haemorrhage06.10.03.002; 24.07.05.0110.000043%-
Chronic gastritis07.08.02.005; 10.04.04.011; 11.07.01.0160.000065%-
Coeliac disease07.17.01.008; 10.04.04.012; 14.02.01.007---
Coronary artery embolism02.02.01.013; 24.01.05.0070.000043%-
Dermatitis herpetiformis10.04.02.014; 23.03.01.0290.000148%-
Diverticulum intestinal haemorrhagic07.10.01.003; 24.07.02.0430.000521%-
Drop attacks15.05.04.018; 17.05.02.0160.000043%-
Extravasation blood24.07.01.0670.000065%-
Gastrointestinal angiodysplasia07.15.04.001; 24.03.03.0070.000217%-
Haemorrhagic cerebral infarction17.08.01.050; 24.07.04.0260.000195%-
Haemorrhagic infarction24.04.02.0080.000152%-
Hepatic haematoma09.01.06.016; 12.01.17.008; 24.07.01.0710.000087%-
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