Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is indicated for reducing the risk of stroke and systemic embolism in patients who have nonvalvular atrial fibrillation, prophylaxis of deep vein thrombosis(DVT) leading to pulmonary embolism(PE) in patients after a hip or knee replacement surgery, and treatment of DVT and PE to reduce the risk of recurrence[Label,A177565,A6897].
Marketing Status approved
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 52048-0420; 69037-0023; 76397-007; 15308-1221; 24196-190; 58032-2028; 66174-0091; 50193-0893; 65372-1196; 65727-081; 0003-3764; 55154-0612; 59651-051; 70366-001; 14445-149; 12783-0893; 12783-0894; 17381-026; 42765-025; 42816-0894; 58623-0137; 63850-8085; 65129-1344; 66039-925; 66651-921; 69989-0006; 63629-7747; 12658-0440; 53869-0893; 73377-191; 55154-0613; 70518-1861; 71610-662; 67835-0015; 75945-060; 76397-010; 50090-6454; 82982-054; 14501-0089; 16436-0113; 65129-1465; 63629-8432; 14445-014; 53747-062; 53869-0894; 63415-0520; 65015-897; 76072-1017; 14445-150; 42816-0893; 0003-0894; 55111-980; 50090-6451
UNII 3Z9Y7UWC1J
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bowel movement irregularity07.02.03.003---
Pyramidal tract syndrome17.05.05.0030.000043%
Cerebral artery stenosis17.08.02.010; 24.04.06.0230.000065%-
Erosive oesophagitis07.04.05.0040.000087%-
Vascular stent thrombosis08.07.05.002; 24.01.01.0440.000195%-
Skin haemorrhage23.06.07.001; 24.07.01.1030.000482%-
Spontaneous haematoma01.01.03.006; 24.07.01.0540.000560%-
Aortic arteriosclerosis24.04.01.0040.000043%-
Loose tooth07.09.05.0090.000139%-
Bronchial haemorrhage22.03.02.007; 24.07.01.0450.000043%-
Laryngeal haemorrhage12.01.09.009; 22.04.01.005; 24.07.01.051--
Vessel puncture site haematoma08.02.04.002; 12.07.04.003; 24.07.01.0180.000043%-
Sphincter of Oddi dysfunction07.18.02.002; 09.02.02.0040.000065%-
Treatment failure08.06.01.0170.002616%-
Regurgitation07.01.07.0040.000043%-
Haemorrhagic erosive gastritis07.04.03.008; 24.07.02.0370.000043%-
Abdominal wall haemorrhage07.16.05.002; 12.01.17.002; 24.07.02.0360.000087%-
Neurological decompensation17.02.05.0300.000108%-
Acute kidney injury20.01.03.016--
Procedural haemorrhage12.02.05.036; 24.07.01.053--
Central nervous system haemorrhage17.08.01.035; 24.07.04.0160.000108%-
Peripheral artery thrombosis24.01.02.0100.000260%-
Application site haemorrhage08.02.01.040; 12.07.01.040; 24.07.01.048---
Microembolism24.01.01.0250.000087%-
Autoimmune haemolytic anaemia01.06.01.004; 10.04.01.0050.000174%-
Peripheral venous disease24.04.02.0220.000291%-
Sinus node dysfunction02.03.03.0170.000174%
Spinal cord haematoma12.01.13.005; 17.08.01.037; 24.07.04.0190.000174%-
Perforation08.01.03.0580.000065%-
Stenosis08.01.03.0600.000065%-
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