Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is indicated for reducing the risk of stroke and systemic embolism in patients who have nonvalvular atrial fibrillation, prophylaxis of deep vein thrombosis(DVT) leading to pulmonary embolism(PE) in patients after a hip or knee replacement surgery, and treatment of DVT and PE to reduce the risk of recurrence[Label,A177565,A6897].
Marketing Status approved
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 52048-0420; 69037-0023; 76397-007; 15308-1221; 24196-190; 58032-2028; 66174-0091; 50193-0893; 65372-1196; 65727-081; 0003-3764; 55154-0612; 59651-051; 70366-001; 14445-149; 12783-0893; 12783-0894; 17381-026; 42765-025; 42816-0894; 58623-0137; 63850-8085; 65129-1344; 66039-925; 66651-921; 69989-0006; 63629-7747; 12658-0440; 53869-0893; 73377-191; 55154-0613; 70518-1861; 71610-662; 67835-0015; 75945-060; 76397-010; 50090-6454; 82982-054; 14501-0089; 16436-0113; 65129-1465; 63629-8432; 14445-014; 53747-062; 53869-0894; 63415-0520; 65015-897; 76072-1017; 14445-150; 42816-0893; 0003-0894; 55111-980; 50090-6451
UNII 3Z9Y7UWC1J
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Vitreous haemorrhage06.10.03.001; 24.07.05.0050.000269%
Post thrombotic syndrome24.01.01.0190.000174%-
Intestinal polyp07.20.01.009; 16.05.01.0020.000356%-
Intracardiac thrombus02.11.01.017; 24.01.05.0030.000941%-
Wound secretion08.01.03.035; 12.01.08.007---
Axillary pain08.01.08.0150.000095%-
Underweight14.03.02.0170.000117%-
Ischaemic cardiomyopathy02.04.01.004; 24.04.04.0190.000108%-
Carotid artery occlusion17.08.01.012; 24.04.06.0080.000152%-
Spinal cord haemorrhage12.01.13.003; 17.08.01.030; 24.07.04.0100.000542%-
Weight fluctuation14.03.02.0020.000360%-
Chapped lips07.05.01.004---
Oesophagitis ulcerative07.04.05.0030.000043%-
Tachyarrhythmia02.03.02.0080.000195%-
Anal haemorrhage07.12.03.004; 24.07.02.0290.000217%
Muscle fatigue15.05.03.006---
Urethral haemorrhage20.07.01.003; 24.07.03.0060.000247%-
Tumour haemorrhage16.32.03.008; 24.07.01.0280.000824%
Pituitary haemorrhage05.03.04.005; 17.08.01.019; 24.07.04.0090.000065%-
Shock haemorrhagic14.05.05.003; 24.06.02.0140.001931%-
Dry gangrene23.06.06.003; 24.04.03.0180.000043%-
Idiosyncratic drug reaction08.06.01.0020.000043%-
Cervix haemorrhage uterine21.06.01.005; 24.07.03.011---
Urogenital haemorrhage20.08.01.006; 21.10.05.008; 24.07.01.0440.000195%-
Spinal epidural haematoma12.01.13.006; 17.08.01.038; 24.07.04.0200.000152%-
Carotid sinus syndrome17.04.06.001; 24.03.04.0020.000043%-
Scleral haemorrhage06.07.01.002; 24.07.05.0090.000043%-
Contusion12.01.06.001; 15.03.05.007; 23.03.11.002; 24.07.06.001--
Lower gastrointestinal haemorrhage07.12.03.011; 24.07.02.0300.001809%
Deep vein thrombosis24.01.02.0030.017389%-
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