Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Anakinra
Drug ID BADD_D00141
Description Anakinra is a recombinant, nonglycosylated human interleukin-1 receptor antagonist (IL-1Ra). The difference between anakinra and the native human IL-1Ra is that anakinra has an extra methionine residue at the amino terminus. It is manufactured by using the E. coli expression system. Anakinra is composed of 153 amino acid residues. FDA approved on November 14, 2001 for the treatment of rheumatoid arthritis.
Indications and Usage For the treatment of adult rheumatoid arthritis and treatment of Neonatal-Onset Multisystem Inflammatory Disease (NOMID).
Marketing Status Prescription
ATC Code L04AC03
DrugBank ID DB00026
KEGG ID D02934
MeSH ID D053590
PubChem ID Not Available
TTD Drug ID D02DES
NDC Product Code 66658-234; 68225-067
Synonyms Interleukin 1 Receptor Antagonist Protein | IL1 Febrile Inhibitor | Febrile Inhibitor, IL1 | IL-1Ra | Urine-Derived IL1 Inhibitor | IL1 Inhibitor, Urine-Derived | Urine Derived IL1 Inhibitor | IL-1 Inhibitor, Urine | IL 1 Inhibitor, Urine | Urine IL-1 Inhibitor | Interleukin 1 Inhibitor, Urine | Antril | Kineret | Anakinra
Chemical Information
Molecular Formula Not Available
CAS Registry Number 143090-92-0
SMILES Not Available
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Angioedema10.01.05.009; 23.04.01.001--Not Available
Arthralgia15.01.02.001--
Cellulitis11.02.01.001; 23.09.01.001--Not Available
Diarrhoea07.02.01.001--
Headache17.14.01.001--
Infection11.01.08.002--Not Available
Influenza like illness08.01.03.010--
Injection site erythema08.02.03.001; 12.07.03.001; 23.03.06.015--Not Available
Injection site haemorrhage08.02.03.005; 12.07.03.005; 24.07.01.010--Not Available
Injection site inflammation08.02.03.008; 12.07.03.009--Not Available
Injection site pain08.02.03.010; 12.07.03.011--Not Available
Injection site reaction08.02.03.014; 12.07.03.015--
Lymphoma01.12.01.001; 16.20.01.001--Not Available
Nausea07.01.07.001--
Neutropenia01.02.03.004--Not Available
Osteomyelitis11.01.01.001; 15.02.05.001--
Pneumonia11.01.09.003; 22.07.01.003--Not Available
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Rheumatoid arthritis10.04.06.001; 15.01.03.001--Not Available
Sinusitis11.01.13.005; 22.07.03.007--
Upper respiratory tract infection11.01.13.009; 22.07.03.011--
Urticaria10.01.06.001; 23.04.02.001--
White blood cell count decreased13.01.06.012--
Arthritis infective11.01.01.003; 15.01.05.002--
Antibody test positive13.06.03.001--Not Available
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