Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Amoxicillin
Drug ID BADD_D00129
Description Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972.[A190648] Amoxicillin has similar activity to [penicillin] and [ampicillin], but leads to higher serum concentrations than ampicillin.[A190648] Amoxicillin was granted FDA approval on 18 January 1974.[L11644]
Indications and Usage Amoxicillin alone is indicated to treat susceptible bacterial infections of the ear, nose, throat, genitourinary tract, skin, skin structure, and lower respiratory tract.[L11656,L11659] Amoxicillin is given with calvulanic acid to treat acute bacterial sinusitis, community acquired pneumonia, lower respiratory tract infections, acute bacterial otitis media, skin and skin structure infections, and urinary tract infections.[L11650,L7880,L11653] Amoxicillin is given with omeprazole in the treatment of _H. pylori_.[L9743,L11647]
Marketing Status approved; vet_approved
ATC Code J01CA04
DrugBank ID DB01060
KEGG ID D00229; D07452
MeSH ID D000658
PubChem ID 33613
TTD Drug ID D0F6EO
NDC Product Code 0781-5060; 55657-101; 55657-106; 59651-099; 65862-274; 0093-2268; 0093-4161; 43063-563; 0143-9886; 50090-0304; 50090-0858; 50090-1511; 50090-5863; 50090-5880; 51655-156; 53002-0130; 53002-2080; 55289-182; 57237-029; 61919-672; 61919-716; 63187-200; 63187-591; 68071-1760; 68071-2908; 68071-4548; 68788-8240; 70518-0895; 72789-224; 76420-192; 81964-225; 43063-820; 50090-0713; 50090-6056; 50090-6466; 53002-1369; 55289-019; 57237-028; 61919-401; 63187-044; 63187-295; 65862-071; 65862-706; 67296-1156; 68071-4455; 68788-7318; 68788-9948; 70518-2188; 70518-2190; 70518-3294; 71205-177; 71205-436; 76420-112; 76420-508; 0781-6039; 0093-4160; 0143-9285; 43063-341; 63187-262; 63629-7587; 63629-7798; 63629-7801; 68071-2766; 68071-2875; 68071-3119; 68788-6374; 68999-825; 55289-020; 63187-043; 63187-186; 63629-7633; 66267-994; 67296-1894; 68071-4693; 68071-4741; 68788-8324; 71205-035; 71205-422; 0781-6041; 16714-299; 0093-2267; 42571-234; 42708-153; 43063-574; 50090-0288; 50090-1512; 50090-1812; 50090-6351; 53002-2369; 63187-027; 67296-0986; 68071-2558; 68788-8209; 68788-8304; 68788-8325; 68788-9018; 71205-507; 76420-003; 52115-001; 65862-014; 65862-017; 50090-0406; 50090-0407; 50090-6469; 53002-2160; 57237-032; 63187-325; 68071-4953; 70518-2191; 70882-113; 70934-038; 76420-545; 16714-298; 0093-2264; 42708-010; 42708-076; 0143-9888; 0143-9939; 50090-1810; 53002-2090; 63187-029; 63187-399; 63187-880; 65862-707; 68071-2604; 70518-3234; 70882-114; 71205-266; 72789-254; 0781-2613; 0781-5061; 0781-6156; 42708-112; 43063-885; 50090-0301; 50090-0404; 50090-1086; 50090-1347; 61919-135; 63187-013; 63187-335; 63187-343; 63187-729; 65862-015; 65862-016; 65862-070; 68071-2320; 68071-2911; 70518-3228; 76420-573; 80425-0269; 0093-3109; 0093-4155; 50090-1513; 50090-1813; 50090-2251; 50090-6349; 57237-031; 61919-994; 63629-7585; 67296-1126; 68071-1826; 68788-6369; 68788-7323; 68788-8352; 68788-9019; 72189-463; 72789-225; 0781-6157; 81964-205; 83112-031; 0093-2263; 42571-233; 0143-9887; 50090-1826; 50090-6319; 50090-6355; 50436-0031; 53002-2091; 57237-033; 68071-3235; 68788-7414; 68788-9017; 68788-9949; 70934-064; 71205-775; 72189-285; 0781-2020; 76420-138; 82982-022; 0093-3107; 42708-078; 43063-915; 0143-9889; 50090-0302; 50090-0303; 50090-0405; 50090-0709; 50090-1811; 50090-6323; 57237-030; 59115-041
UNII 804826J2HU
Synonyms Amoxicillin | Amoxycillin | Amoxicilline | Amoxicillin Monopotassium Salt | Hydroxyampicillin | Amoxicillin Sodium | Amoxicillin Monosodium Salt | Amoxicillin, (R*)-Isomer | Amoxicillin Anhydrous | Actimoxi | BRL-2333 | BRL 2333 | BRL2333 | Clamoxyl | Penamox | Clamoxyl Parenteral | Clamoxyl G.A. | Polymox | Trimox | Wymox | Amoxicillin Trihydrate | Amoxil
Chemical Information
Molecular Formula C16H19N3O5S
CAS Registry Number 26787-78-0
SMILES CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)C(=O)O)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Foetal death08.04.01.011; 18.01.02.0030.000005%
Haemorrhage24.07.01.002---
Fluid intake reduced14.05.10.0010.000005%-
Vulvovaginal pruritus21.08.02.004; 23.03.12.009---
Pharyngeal erythema22.04.05.0100.000005%-
Temperature intolerance08.01.09.022---
Rectal tenesmus07.03.03.001; 15.05.03.0110.000005%-
Hypoaesthesia oral07.05.05.003; 17.02.06.0210.000007%-
Paraesthesia oral07.05.05.035; 17.02.06.0080.000053%-
Toxic skin eruption10.01.01.008; 12.03.01.073; 23.03.05.0030.000148%-
Ocular icterus01.06.04.007; 06.08.03.009; 09.01.01.0070.000007%-
Pulseless electrical activity02.03.04.0200.000007%-
Skin oedema23.06.04.0010.000005%-
Abdominal symptom07.01.06.0070.000010%-
Biliary tract disorder09.02.03.0010.000007%-
Feeding disorder14.03.02.003; 19.09.01.0030.000015%-
Infestation11.09.01.001; 23.11.01.002---
Jaw disorder15.02.04.009---
Motor dysfunction15.05.06.006; 17.01.02.0310.000005%-
Abnormal behaviour19.01.01.0010.000063%-
Decreased appetite08.01.09.028; 14.03.01.005--
Corneal disorder06.08.01.0040.000005%-
Feeling of body temperature change08.01.09.0120.000005%-
Sebaceous gland disorder23.02.07.0040.000005%-
Sensation of foreign body08.01.09.0020.000026%-
Urinary tract obstruction20.08.01.0040.000007%
Blood disorder01.05.01.004---
Obstructive airways disorder22.03.01.0110.000007%-
Food intolerance14.02.01.005---
Hepatobiliary disease09.01.08.003---
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ADReCS-Target
Drug Name ADR Term Target
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