| Drug Name |
Amiloride hydrochloride |
| Drug ID |
BADD_D00105 |
| Description |
A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with diuretics to spare potassium loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705) |
| Indications and Usage |
For use as adjunctive treatment with thiazide diuretics or other kaliuretic-diuretic agents in congestive heart failure or hypertension. |
| Marketing Status |
approved |
| ATC Code |
C03DB01 |
| DrugBank ID |
DB00594
|
| KEGG ID |
D00649
|
| MeSH ID |
D000584
|
| PubChem ID |
16230
|
| TTD Drug ID |
D0I0RJ
|
| NDC Product Code |
63629-2114; 57721-671; 0574-0292; 49884-117; 42794-005; 17337-0500 |
| UNII |
FZJ37245UC
|
| Synonyms |
Amiloride | Amiduret Trom | Trom, Amiduret | Amiloberag | Midoride | Amiloride Hydrochloride, Anhydrous | Anhydrous Amiloride Hydrochloride | Hydrochloride, Anhydrous Amiloride | Kaluril | Midamor | Modamide | Amidal | Amiloride Hydrochloride | Hydrochloride, Amiloride |
