Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alvimopan
Drug ID BADD_D00096
Description Alvimopan is a peripherally acting μ opioid antagonist. It is used to avoid postoperative ileus following small or large bowel resection and accelerates the gastrointestinal recovery period.
Indications and Usage Used to accelerate the time to upper and lower gastrointestinal recovery following partial large or small bowel resection surgery with primary anastomosis. Also investigated for use in the treatment of pain (acute or chronic).
Marketing Status approved; investigational
ATC Code A06AH02
DrugBank ID DB06274
KEGG ID D02878
MeSH ID C419502
PubChem ID 5488548
TTD Drug ID D0D7KC
NDC Product Code 67919-020; 0591-2312; 55679-111; 0254-3012
UNII 677C126AET
Synonyms alvimopan | trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine | alvimopan anhydrous | anhydrous alvimopan | LY 246736 | LY246736 | LY-246736 | ADL 8-2698 | ADL8-2698 | Entereg
Chemical Information
Molecular Formula C25H32N2O4
CAS Registry Number 156053-89-3
SMILES CC1CN(CCC1(C)C2=CC(=CC=C2)O)CC(CC3=CC=CC=C3)C(=O)NCC(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaemia01.03.02.001--
Back pain15.03.04.005--
Constipation07.02.02.001--
Dyspepsia07.01.02.001--
Flatulence07.01.04.002--
Gastrointestinal disorder07.11.01.001---
Hypokalaemia14.05.03.002--
Urethral disorder20.07.01.002---
Urinary retention20.02.02.011--
Urinary tract disorder20.08.01.001---
Lymphatic disorder01.09.01.003---
Connective tissue disorder10.04.04.026; 15.06.01.006---
Malnutrition14.03.02.004---
Blood disorder01.05.01.004---
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