Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Altretamine
Drug ID BADD_D00088
Description An alkylating agent proposed as an antineoplastic. It also acts as a chemosterilant for male houseflies and other insects.
Indications and Usage For use as a single agent in the palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and/or alkylating agent-based combination.
Marketing Status Prescription
ATC Code L01XX03
DrugBank ID DB00488
KEGG ID D02841
MeSH ID D006585
PubChem ID 2123
TTD Drug ID D02LPF
NDC Product Code Not Available
Synonyms Altretamine | Hemel | Hexamethylmelamine | Hexinawas | Hexalen | Hexastat
Chemical Information
Molecular Formula C9H18N6
CAS Registry Number 645-05-6
SMILES CN(C)C1=NC(=NC(=N1)N(C)C)N(C)C
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Affective disorder19.04.04.001--Not Available
Alopecia23.02.02.001--
Altered state of consciousness17.02.04.001; 19.07.01.003--Not Available
Anaemia01.03.02.001--
Asthenia08.01.01.001--Not Available
Ataxia08.01.02.004; 17.02.02.001--
Blood creatinine13.13.01.020--Not Available
Blood urea13.13.01.019--Not Available
Dizziness02.01.02.004; 17.02.05.003; 24.06.02.007--
Fatigue08.01.01.002--
Hepatotoxicity09.01.07.009; 12.03.01.008--Not Available
Leukopenia01.02.02.001--Not Available
Nausea07.01.07.001--
Neoplasm16.16.02.001--Not Available
Neoplasm malignant16.16.01.001--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neurotoxicity12.03.01.011; 17.02.10.002--Not Available
Ovarian cancer16.12.04.001; 21.11.01.003--Not Available
Pancytopenia01.03.03.003--Not Available
Peripheral sensory neuropathy17.09.03.005--
Platelet count13.01.04.011--Not Available
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Seizure17.12.03.001--
Thrombocytopenia01.08.01.002--Not Available
Vertigo04.04.01.003; 17.02.12.002--
Vomiting07.01.07.003--
Blood alkaline phosphatase increased13.04.02.004--
Neurological symptom17.02.05.010--Not Available
Decreased appetite08.01.09.028; 14.03.01.005--
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