Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Altretamine
Drug ID BADD_D00088
Description An alkylating agent proposed as an antineoplastic. It also acts as a chemosterilant for male houseflies and other insects.
Indications and Usage For use as a single agent in the palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and/or alkylating agent-based combination.
Marketing Status approved
ATC Code L01XX03
DrugBank ID DB00488
KEGG ID D02841
MeSH ID D006585
PubChem ID 2123
TTD Drug ID D02LPF
NDC Product Code Not Available
UNII Q8BIH59O7H
Synonyms Altretamine | Hemel | Hexamethylmelamine | Hexinawas | Hexalen | Hexastat
Chemical Information
Molecular Formula C9H18N6
CAS Registry Number 645-05-6
SMILES CN(C)C1=NC(=NC(=N1)N(C)C)N(C)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Affective disorder19.04.04.001---
Alopecia23.02.02.001--
Altered state of consciousness17.02.04.001; 19.07.01.003---
Anaemia01.03.02.001--
Asthenia08.01.01.001---
Ataxia08.01.02.004; 17.02.02.001--
Blood creatinine13.13.01.020---
Blood urea13.13.01.019---
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Fatigue08.01.01.002--
Hepatotoxicity09.01.07.009; 12.03.01.008---
Leukopenia01.02.02.001---
Nausea07.01.07.001--
Neoplasm16.16.02.001---
Neoplasm malignant16.16.01.001---
Neuropathy peripheral17.09.03.003---
Neurotoxicity12.03.01.011; 17.02.10.002---
Ovarian cancer16.12.04.001; 21.11.01.003---
Pancytopenia01.03.03.003---
Peripheral sensory neuropathy17.09.03.005--
Platelet count13.01.04.011---
Pruritus23.03.12.001--
Rash23.03.13.001---
Seizure17.12.03.001--
Thrombocytopenia01.08.01.002---
Vertigo04.04.01.003; 17.02.12.002--
Vomiting07.01.07.003--
Blood alkaline phosphatase increased13.04.02.004--
Neurological symptom17.02.05.010---
Decreased appetite08.01.09.028; 14.03.01.005--
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