Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alogliptin
Drug ID BADD_D00079
Description Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25, 2013.
Indications and Usage Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Marketing Status Prescription
ATC Code A10BH04
DrugBank ID DB06203
KEGG ID D06553
MeSH ID C520853
PubChem ID 11450633
TTD Drug ID D0NJ5H
NDC Product Code 65392-2813; 64764-625; 11532-7002; 71610-300; 66332-7003; 45802-150; 64764-250; 64764-125; 45802-103; 45802-087; 11532-7003; 50090-5574; 11532-7001; 66332-7002; 66332-7001
Synonyms alogliptin | 2-((6-((3R)-3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl) benzonitrile | nesina | SYR 322 | SYR322 | SYR-322
Chemical Information
Molecular Formula C18H21N5O2
CAS Registry Number 850649-61-5
SMILES CN1C(=O)C=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCCC(C3)N
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Thrombocytopenia01.08.01.002--Not Available
Upper respiratory tract infection11.01.13.009; 22.07.03.0110.000300%
Urticaria10.01.06.001; 23.04.02.0010.000701%
Vertigo04.04.01.003; 17.02.12.0020.000200%
Vomiting07.01.07.0030.001201%
Weight decreased13.15.01.005--
Tubulointerstitial nephritis20.05.02.0020.000200%Not Available
Peripheral swelling02.05.04.015; 08.01.03.0530.000200%Not Available
Lung neoplasm malignant16.19.02.001; 22.08.01.0010.000131%Not Available
Prostate cancer16.25.01.001; 21.04.02.0020.000052%Not Available
Hyperinsulinism05.06.03.007; 14.06.03.0070.000200%Not Available
Decreased appetite08.01.09.028; 14.03.01.005--
Disease progression08.01.03.038--
Renal impairment20.01.03.0100.000300%Not Available
Hyperamylasaemia14.11.01.0030.000200%Not Available
Chronic kidney disease20.01.03.0170.000200%
Bone marrow failure01.03.03.0050.000200%
Acute kidney injury20.01.03.016--
Drug-induced liver injury09.01.07.023; 12.03.01.0440.000300%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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