Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alogliptin
Drug ID BADD_D00079
Description Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25, 2013.
Indications and Usage Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Marketing Status Prescription
ATC Code A10BH04
DrugBank ID DB06203
KEGG ID D06553
MeSH ID C520853
PubChem ID 11450633
TTD Drug ID D0NJ5H
NDC Product Code 65392-2813; 64764-625; 11532-7002; 71610-300; 66332-7003; 45802-150; 64764-250; 64764-125; 45802-103; 45802-087; 11532-7003; 50090-5574; 11532-7001; 66332-7002; 66332-7001
Synonyms alogliptin | 2-((6-((3R)-3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl) benzonitrile | nesina | SYR 322 | SYR322 | SYR-322
Chemical Information
Molecular Formula C18H21N5O2
CAS Registry Number 850649-61-5
SMILES CN1C(=O)C=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCCC(C3)N
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Intestinal obstruction07.13.01.0020.001001%Not Available
Jaundice01.06.04.004; 09.01.01.004; 23.03.03.0300.000200%Not Available
Liver disorder09.01.08.0010.000501%Not Available
Malaise08.01.01.003--
Marasmus14.03.02.0130.000052%Not Available
Musculoskeletal pain15.03.04.0070.000200%
Myalgia15.05.02.0010.000300%
Nasopharyngitis11.01.13.002; 22.07.03.002--Not Available
Nausea07.01.07.0010.001402%
Neoplasm malignant16.16.01.0010.000104%Not Available
Oedema08.01.07.006; 14.05.06.0100.000200%Not Available
Oedema peripheral02.05.04.007; 08.01.07.007; 14.05.06.0110.000200%
Pancreatic carcinoma07.21.09.002; 16.13.10.0010.000183%Not Available
Pancreatitis07.18.01.0010.001101%
Pancreatitis acute07.18.01.0020.001502%Not Available
Pemphigoid10.04.02.002; 23.03.01.0040.002002%Not Available
Pemphigus10.04.02.003; 23.03.01.0050.000200%Not Available
Photosensitivity reaction23.03.09.0030.000300%
Platelet count decreased13.01.04.0010.000300%
Pneumonia11.01.09.003; 22.07.01.0030.000601%Not Available
Pruritus23.03.12.0010.000601%
Pyrexia08.05.02.0030.000601%
Rash23.03.13.0010.001402%Not Available
Rash generalised23.03.13.0020.000300%Not Available
Rash papular23.03.13.0170.000200%Not Available
Rhabdomyolysis15.05.05.0020.000601%
Serum sickness10.01.03.004; 12.02.08.004--
Skin exfoliation23.03.07.0030.000200%Not Available
Stevens-Johnson syndrome10.01.03.020; 11.07.01.005; 12.03.01.014; 23.03.01.0070.000501%
Sudden death02.03.04.013; 08.04.01.0030.000052%
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ADReCS-Target
Drug Name ADR Term Target
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