Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alogliptin
Drug ID BADD_D00079
Description Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25, 2013.
Indications and Usage Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Marketing Status approved
ATC Code A10BH04
DrugBank ID DB06203
KEGG ID D06553
MeSH ID C520853
PubChem ID 11450633
TTD Drug ID D0NJ5H
NDC Product Code 64764-250; 45802-087; 66332-7001; 66332-7003; 45802-103; 11532-7001; 71610-300; 64764-125; 64764-625; 11532-7002; 45802-150; 71610-661; 65392-2813; 50090-5574; 66332-7002; 11532-7003
UNII JHC049LO86
Synonyms alogliptin | 2-((6-((3R)-3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl) benzonitrile | nesina | SYR 322 | SYR322 | SYR-322
Chemical Information
Molecular Formula C18H21N5O2
CAS Registry Number 850649-61-5
SMILES CN1C(=O)C=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCCC(C3)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Erythema multiforme10.01.03.015; 23.03.01.0030.001396%
Feeling abnormal08.01.09.0140.001555%-
Flatulence07.01.04.0020.001356%
Gastric cancer07.21.02.001; 16.13.03.0010.000598%-
Gastrooesophageal reflux disease07.02.02.0030.000598%
Gastrointestinal disorder07.11.01.0010.000399%-
Headache17.14.01.001--
Hepatic function abnormal09.01.02.0010.001396%-
Hyperglycaemia05.06.02.002; 14.06.02.0020.000399%
Hypersensitivity10.01.03.003--
Hypoglycaemia05.06.03.001; 14.06.03.0010.001595%
Hyponatraemia14.05.04.0020.000399%
Ileus07.13.01.0010.000997%
Interstitial lung disease10.02.01.033; 22.01.02.0030.002991%-
Intestinal obstruction07.13.01.0020.001994%-
Jaundice01.06.04.004; 09.01.01.004; 23.03.03.0300.000399%-
Lactic acidosis14.01.01.0020.000399%-
Liver disorder09.01.08.0010.001476%-
Marasmus14.03.02.0130.000399%-
Musculoskeletal pain15.03.04.0070.001356%
Myalgia15.05.02.0010.002233%
Myelodysplastic syndrome01.10.04.001; 16.01.04.0010.000399%
Nasopharyngitis11.01.13.002; 22.07.03.002---
Nausea07.01.07.0010.008455%
Neoplasm malignant16.16.01.0010.000798%-
Oedema08.01.07.006; 14.05.06.0100.000877%-
Oedema peripheral02.05.04.007; 08.01.07.007; 14.05.06.0110.002034%
Pancreatic carcinoma07.21.09.002; 16.13.10.0010.001396%-
Pancreatitis07.18.01.0010.004546%
Pancreatitis acute07.18.01.0020.003789%-
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ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene