Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alogliptin
Drug ID BADD_D00079
Description Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25, 2013.
Indications and Usage Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Marketing Status approved
ATC Code A10BH04
DrugBank ID DB06203
KEGG ID D06553
MeSH ID C520853
PubChem ID 11450633
TTD Drug ID D0NJ5H
NDC Product Code 64764-250; 45802-087; 66332-7001; 66332-7003; 45802-103; 11532-7001; 71610-300; 64764-125; 64764-625; 11532-7002; 45802-150; 71610-661; 65392-2813; 50090-5574; 66332-7002; 11532-7003
UNII JHC049LO86
Synonyms alogliptin | 2-((6-((3R)-3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl) benzonitrile | nesina | SYR 322 | SYR322 | SYR-322
Chemical Information
Molecular Formula C18H21N5O2
CAS Registry Number 850649-61-5
SMILES CN1C(=O)C=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCCC(C3)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acute hepatic failure09.01.03.001---
Acute myocardial infarction02.02.02.001; 24.04.04.0010.000399%-
Altered state of consciousness17.02.04.001; 19.07.01.0030.000399%-
Anaemia01.03.02.0010.000997%
Anaphylactic reaction10.01.07.001; 24.06.03.0060.000399%
Anaphylactic shock10.01.07.002; 24.06.02.004---
Anaphylactoid reaction10.01.07.003; 24.06.03.0070.000877%-
Angina pectoris02.02.02.002; 24.04.04.0020.000798%
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.0010.001196%-
Arthralgia15.01.02.0010.002712%
Back pain15.03.04.0050.001555%
Bile duct cancer09.04.02.001; 16.07.01.0010.001196%-
Blister12.01.06.002; 23.03.01.0010.000399%-
Cardiac failure02.05.01.0010.000798%
Cataract06.06.01.0010.000399%
Cerebral haemorrhage17.08.01.003; 24.07.04.0010.000399%-
Cerebral infarction17.08.01.004; 24.04.06.0020.000997%-
Cholecystitis09.03.01.0010.000399%
Colitis ischaemic07.08.01.004; 24.04.08.0120.000399%-
Colon cancer07.21.01.001; 16.13.01.0010.001595%-
Condition aggravated08.01.03.0040.002672%-
Constipation07.02.02.0010.001276%
Dermatitis23.03.04.002---
Diabetes mellitus05.06.01.001; 14.06.01.0010.000598%-
Diabetic neuropathy05.07.04.003; 14.07.04.003; 17.09.04.0020.000399%-
Drug eruption08.01.06.015; 10.01.01.005; 23.03.05.0010.002273%-
Dyspnoea exertional02.11.05.005; 22.02.01.0050.001555%-
Eczema23.03.04.0060.001077%
Enterocolitis07.08.03.0030.000598%
Erythema23.03.06.0010.001476%-
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ADReCS-Target
Drug Name ADR Term Target
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