Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alfuzosin
Drug ID BADD_D00069
Description Benign prostatic hyperplasia (BPH) refers to a benign growth or hyperplasia of the prostate and leads to lower urinary tract symptoms in men, such as urgency, frequency and changes to urine flow. The prevalence of BPH is as high as 50%-60% for males in their 60's, and this prevalence increases to 80%-90% of those over 70.[A228483] Alfuzosin is an alpha-1 adrenergic blocker used in the symptomatic treatment of BPH that works by relaxing the muscles in the prostate and bladder neck.[L31593] It was initially approved by the FDA in 2003 and is marketed by several pharmaceutical companies.[L9251]
Indications and Usage Alfuzosin is used to treat the signs and symptoms of benign prostatic hyperplasia (BPH).[L9251]
Marketing Status approved; investigational
ATC Code G04CA01
DrugBank ID DB00346
KEGG ID D07124
MeSH ID C047638
PubChem ID 2092
TTD Drug ID D09MWJ
NDC Product Code Not Available
UNII 90347YTW5F
Synonyms alfuzosin | alphuzosine | N-(3-((4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino)propyl)tetrahydro-2-furancarboxamide | alfusozine | alfuzosin hydrochloride | UroXatral | Benestan | Urion | Xatral | Alfetim
Chemical Information
Molecular Formula C19H27N5O4
CAS Registry Number 81403-80-7
SMILES CN(CCCNC(=O)C1CCCO1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Ear disorder04.03.01.001---
Eye disorder06.08.03.001---
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014---
Flushing08.01.03.025; 23.06.05.003; 24.03.01.002--
Gastrointestinal disorder07.11.01.001---
Gastrointestinal pain07.01.05.005--
Hallucination19.10.04.0030.000652%
Headache17.14.01.001--
Hepatocellular injury09.01.07.008---
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hyponatraemia14.05.04.0020.000652%
Hypotension24.06.03.002--
Infection11.01.08.002---
Influenza like illness08.01.03.010--
Injury12.01.08.004---
Jaundice01.06.04.004; 09.01.01.004; 23.03.03.030---
Laryngitis11.01.13.001; 22.07.03.001--
Loss of consciousness17.02.04.004---
Malaise08.01.01.003--
Miosis06.05.03.003; 17.02.11.002---
Nausea07.01.07.001--
Nephrolithiasis20.04.01.002--
Nervous system disorder17.02.10.001---
Neuralgia17.02.07.005--
Neuropathy peripheral17.09.03.003---
Nocturia20.02.03.001---
Oedema08.01.07.006; 14.05.06.010---
Orthostatic hypotension17.05.01.020; 24.06.03.004---
Osteoarthritis15.01.04.001---
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