Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alcaftadine
Drug ID BADD_D00058
Description Alcaftadine is a H1 histamine receptor antagonist indicated for the prevention of itching associated with allergic conjunctivitis. This drug was approved in July 2010.
Indications and Usage For the prevention of itching associated with allergic conjunctivitis.
Marketing Status approved
ATC Code S01GX11
DrugBank ID DB06766
KEGG ID D06552
MeSH ID C557708
PubChem ID 19371515
TTD Drug ID D0O7JW
NDC Product Code 65089-0063; 58602-605; 42973-204; 14501-0020; 12502-5263; 0023-4290; 0023-4291
UNII 7Z8O94ECSX
Synonyms alcaftadine
Chemical Information
Molecular Formula C19H21N3O
CAS Registry Number 147084-10-4
SMILES CN1CCC(=C2C3=CC=CC=C3CCN4C2=NC=C4C=O)CC1
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Burning sensation08.01.09.029; 17.02.06.001---
Condition aggravated08.01.03.0040.004663%-
Conjunctival oedema06.04.01.0010.008266%-
Corneal oedema06.04.02.0010.004663%-
Dermatitis allergic10.01.03.014; 23.03.04.003---
Drug hypersensitivity10.01.01.0010.019075%-
Erythema23.03.06.0010.007206%-
Erythema of eyelid06.04.04.003; 23.03.06.0060.043238%-
Eye allergy06.04.05.010; 10.01.03.0280.007206%-
Eye discharge06.04.05.0010.025222%-
Eye disorder06.08.03.0010.010809%-
Eye inflammation06.04.05.0020.018016%-
Eye irritation06.04.05.0030.132892%-
Eye pain06.08.03.0020.066976%
Eye swelling06.08.03.0030.058710%-
Eyelid oedema06.04.04.004; 10.01.05.001; 23.04.01.0030.046841%-
Eyelid ptosis06.05.01.002; 17.17.02.0040.004663%-
Feeling abnormal08.01.09.0140.005723%-
Headache17.14.01.0010.011869%
Hyperaemia24.03.02.0020.007206%-
Hypersensitivity10.01.03.0030.030945%
Influenza11.05.03.001; 22.07.02.001---
Influenza like illness08.01.03.0100.010809%
Instillation site pain08.02.01.008; 12.07.01.0080.022679%-
Keratitis06.04.02.0020.002119%
Lacrimation increased06.08.02.0040.021619%
Nasopharyngitis11.01.13.002; 22.07.03.002---
Ocular hyperaemia06.04.05.0040.219367%-
Pain08.01.08.004--
Periorbital oedema06.08.03.017; 10.01.05.010; 23.04.01.0020.007206%
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