| Drug Name |
Adapalene |
| Drug ID |
BADD_D00042 |
| Description |
Acne vulgaris is a multifactorial disorder of the pilosebaceous unit involving increased sebum production, inflammation, and hyperproliferation/hyperkeratinization of the follicular infundibulum. It is also associated with _Cutibacterium acnes_ (also known as _Propionibacterium acnes_). Adapalene is a third-generation topical retinoid used for the treatment of acne vulgaris.[A193518] Adapalene has similar efficacy but a superior safety profile compared to tretinoin.[A193521] [Tazarotene] is more efficacious than adapalene but is designated as pregnancy category X and hence is contraindicated in pregnant women.[A193518] Adapalene can also be combined with benzoyl peroxide (BPO), which possesses bactericidal properties[A193524], and either adapalene alone, or adapalene BPO combination products, are commonly used to treat mild-to-severe acne.[A193518]
Differin®, produced by Galderma Labs, was first granted FDA approval on May 31st, 1996, as a 0.1% adapalene topical solution. Differin was later made available as 0.1% gel, cream, or lotion, or 0.3% gel products. On December 8th, 2008, Galderma Labs gained FDA approval for Epiduo®, a 0.1% adapalene, 2.5% BPO combination gel.[L12873] |
| Indications and Usage |
Adapalene is indicated for the topical treatment of acne vulgaris in patients aged 12 and over.[L12873] |
| Marketing Status |
approved |
| ATC Code |
D10AD03 |
| DrugBank ID |
DB00210
|
| KEGG ID |
D01112
|
| MeSH ID |
D000068816
|
| PubChem ID |
60164
|
| TTD Drug ID |
D0JC9N
|
| NDC Product Code |
51672-1377; 63629-8791; 0363-0888; 68308-706; 68462-403; 0299-5915; 59726-888; 66993-884; 72559-015; 72657-102; 82034-888; 15308-0716; 22365-120; 0299-5912; 0472-0126; 70000-0043; 36800-088; 0299-4910; 17337-0006; 24196-138; 53296-0068; 90027-010; 0168-0424; 49908-118; 62332-549; 46014-1098; 66039-801; 11410-956; 11673-888; 49967-354; 49967-591; 0316-0143; 71052-556; 73309-390; 45802-453; 0299-5918; 69842-088; 21130-708; 41250-288; 51672-2150 |
| UNII |
1L4806J2QF
|
| Synonyms |
Adapalene | 6-(3-(1-adamantyl)-4-methoxyphenyl)-2-naphthoic acid | CD 271 | 271, CD | CD271 | CD-271 | Adaferin | Differin | Differine |
