Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Acitretin
Drug ID BADD_D00036
Description An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate.
Indications and Usage For the treatment of severe psoriasis in adults.
Marketing Status approved
ATC Code D05BB02
DrugBank ID DB00459
KEGG ID D02754
MeSH ID D017255
PubChem ID 5284513
TTD Drug ID D05QDC
NDC Product Code 17337-0003; 59981-011; 0093-1136; 0115-1752; 42291-087; 62147-0145; 0115-1751; 42794-081; 0378-7020; 71214-0698; 42291-088; 58159-058; 71052-692; 0115-1753; 17337-0004; 71214-0667; 0115-1750; 71214-0668; 71214-0669; 42291-086; 42794-080; 0093-1135; 0093-1138; 62147-0146; 76055-0001; 42794-083; 0378-7023
UNII LCH760E9T7
Synonyms Acitretin | Etretin | Isoacitretin | Isoetretin | Ro 10-1670 | Ro 101670 | Ro-10-1670 | Ro101670 | 13-cis-Acitretin | Neotigason | Soriatane | Acitretin, (Z,E,E,E)-Isomer | Ro-13-7652 | Ro137652 | Ro 13-7652 | Ro 137652
Chemical Information
Molecular Formula C21H26O3
CAS Registry Number 55079-83-9
SMILES CC1=CC(=C(C(=C1C=CC(=CC=CC(=CC(=O)O)C)C)C)C)OC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Fatigue08.01.01.002--
Febrile neutropenia01.02.03.002; 08.05.02.004--
Feeling abnormal08.01.09.014---
Feeling hot08.01.09.009---
Fluid retention14.05.06.002; 20.01.02.003---
Flushing08.01.03.025; 23.06.05.003; 24.03.01.002--
Fungal infection11.03.05.001---
Furuncle11.02.05.008; 23.11.02.009---
Gait disturbance08.01.02.002; 15.03.05.013; 17.02.05.016--
Gamma-glutamyltransferase increased13.03.04.024--
Gastritis07.08.02.001--
Gastroenteritis07.19.03.001; 11.01.07.004---
Gastrointestinal disorder07.11.01.0010.001250%-
Gastrointestinal pain07.01.05.005--
Gingival bleeding07.09.07.001; 24.07.02.010---
Gingival hypertrophy07.09.13.008---
Gingivitis07.09.10.002; 11.01.04.013--
Globulins increased13.09.01.003---
Glossitis07.14.01.001---
Glycosuria20.02.01.005--
Haematocrit decreased13.01.05.001---
Haematocrit increased13.01.05.002---
Haematuria20.02.01.006; 21.10.01.018; 24.07.01.047--
Haemoglobin13.01.05.018---
Haemoglobin decreased13.01.05.003---
Haemoglobin increased13.01.05.004--
Haemorrhoids07.15.03.001; 24.10.02.002--
Hair colour changes23.02.06.001--
Hair texture abnormal23.02.06.004--
Hallucination, visual19.10.04.0070.001250%-
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ADReCS-Target
Drug Name ADR Term Target
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