Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Acitretin
Drug ID BADD_D00036
Description An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate.
Indications and Usage For the treatment of severe psoriasis in adults.
Marketing Status approved
ATC Code D05BB02
DrugBank ID DB00459
KEGG ID D02754
MeSH ID D017255
PubChem ID 5284513
TTD Drug ID D05QDC
NDC Product Code 17337-0003; 59981-011; 0093-1136; 0115-1752; 42291-087; 62147-0145; 0115-1751; 42794-081; 0378-7020; 71214-0698; 42291-088; 58159-058; 71052-692; 0115-1753; 17337-0004; 71214-0667; 0115-1750; 71214-0668; 71214-0669; 42291-086; 42794-080; 0093-1135; 0093-1138; 62147-0146; 76055-0001; 42794-083; 0378-7023
UNII LCH760E9T7
Synonyms Acitretin | Etretin | Isoacitretin | Isoetretin | Ro 10-1670 | Ro 101670 | Ro-10-1670 | Ro101670 | 13-cis-Acitretin | Neotigason | Soriatane | Acitretin, (Z,E,E,E)-Isomer | Ro-13-7652 | Ro137652 | Ro 13-7652 | Ro 137652
Chemical Information
Molecular Formula C21H26O3
CAS Registry Number 55079-83-9
SMILES CC1=CC(=C(C(=C1C=CC(=CC=CC(=CC(=O)O)C)C)C)C)OC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Emotional distress19.04.02.008---
Blood phosphorus decreased13.11.01.015---
Blood phosphorus increased13.11.01.016---
Cerumen impaction04.01.01.001---
Band neutrophil count increased13.01.06.031---
Deep vein thrombosis24.01.02.0030.001875%-
Self-injurious ideation19.12.01.007---
Madarosis06.06.04.010; 23.02.02.004---
Platelet count increased13.01.04.002---
Eyelids pruritus06.08.03.007; 23.03.12.005---
Sticky skin23.03.03.0190.001250%-
Eye pruritus06.04.05.006---
Adenocarcinoma pancreas07.21.09.003; 16.13.10.002---
Drug tolerance decreased08.06.01.024---
Protein urine present13.13.02.006---
Musculoskeletal discomfort15.03.04.001---
Haemorrhage24.07.01.0020.001875%-
Rectal tenesmus07.03.03.001; 15.05.03.011---
Lung neoplasm malignant16.19.02.001; 22.08.01.001---
Dermatitis psoriasiform23.03.14.004---
Disturbance in sexual arousal19.08.04.003---
Congenital eye disorder03.01.01.002; 06.08.03.011---
Angiopathy24.03.02.007---
Blood alkaline phosphatase increased13.04.02.004--
Hot flush08.01.03.027; 21.02.02.001; 24.03.01.005--
Embolism24.01.01.009--
Decreased appetite08.01.09.028; 14.03.01.005--
Erectile dysfunction19.08.04.001; 21.03.01.007--
Ill-defined disorder08.01.03.049---
Lacrimal disorder06.08.02.005---
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ADReCS-Target
Drug Name ADR Term Target
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