Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Acetaminophen
Drug ID BADD_D00023
Description Acetaminophen (paracetamol), also commonly known as _Tylenol_, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO).[A176318] It is also used for its antipyretic effects, helping to reduce fever.[F4124] This drug was initially approved by the U.S. FDA in 1951 and is available in a variety of forms including syrup form, regular tablets, effervescent tablets, injection, suppository, and other forms.[L5756,L5774,F4124,Label] Acetaminophen is often found combined with other drugs in more than 600 over the counter (OTC) allergy medications, cold medications, sleep medications, pain relievers, and other products.[L5783] Confusion about dosing of this drug may be caused by the availability of different formulas, strengths, and dosage instructions for children of different ages.[L5783] Due to the possibility of fatal overdose and liver failure associated with the incorrect use of acetaminophen, it is important to follow current and available national and manufacturer dosing guidelines while this drug is taken or prescribed.[L5786,L5789,Label]
Indications and Usage For temporary relief of fever, minor aches, and pains.
Marketing Status Prescription; OTC; Discontinued
ATC Code N02BE01
DrugBank ID DB00316
KEGG ID D00217
MeSH ID D000082
PubChem ID 1983
TTD Drug ID D0U5QK
NDC Product Code 47682-114; 68016-636; 69842-491; 68094-015; 63868-679; 70000-0310; 45802-201; 68071-4362; 58602-873; 63187-293; 72288-300; 58940-001; 68788-7359; 72036-100; 69842-764; 66326-204; 0615-8398; 68196-484; 70518-0444; 63941-282; 63868-591; 59779-754; 37012-288; 49580-0288; 0121-1314; 0363-9947; 0113-7000; 76281-327; 41250-244; 68210-2002; 69676-0058; 63941-401; 11673-618; 0406-4255; 56062-175; 50090-5313; 49035-531; 0904-6720; 0904-6719; 62011-0434; 71309-077; 0904-6536; 41250-227; 21130-111; 37808-704; 63941-288; 24201-100; 50090-5350; 21130-178; 72288-544; 70000-0137; 0406-6056; 51824-086; 51662-1540; 0113-5002; 62011-0339; 37808-945; 68391-288; 49035-777; 62011-0336; 11822-0519; 41250-246; 69842-707; 68001-495; 69842-297; 68016-029; 68016-333; 70677-0093; 36800-557; 0264-4100; 41250-590; 68998-092; 0615-8397; 69842-636; 50580-209; 70000-0472; 46122-170; 63029-610; 68094-587; 49483-697; 0363-0104; 73173-010; 70677-0018; 46122-552; 36800-770; 56062-130; 69842-793; 59779-946; 71335-0848; 69842-093; 70677-0131; 0904-6749; 55910-661; 68998-001; 56062-484; 50090-0395; 45865-656; 55670-122; 70677-0117; 47682-113; 49580-0685; 59644-9925; 11822-9440; 63981-700; 0615-8409; 53604-703; 55289-880; 71205-478; 0113-4010; 68210-1014; 50580-522; 63868-866; 37808-792; 68788-7709; 69848-003; 36800-369; 0121-0939; 17856-0202; 63187-588; 51672-2115; 50580-433; 57896-221; 54838-144; 30142-157; 62011-0023; 72189-120; 67091-311; 49483-341; 72207-114; 0363-9604; 62011-0238; 41163-514; 58602-745; 70677-0116; 0363-0132; 55315-082; 50580-521; 50580-487; 53604-601; 71399-8025; 0781-9274; 53943-201; 41250-278; 69842-750; 49035-975; 0363-0336; 72476-186; 11822-0107; 58602-220; 51552-0086; 49638-109; 68998-098; 69842-298; 69842-450; 0363-4501; 0113-1889; 63629-1516; 68210-1300; 56062-227; 51645-706; 55910-691; 0363-0971; 0615-8250; 63629-8240; 30142-792; 54738-548; 70729-001; 51013-182; 62011-0001; 62011-0183; 51824-087; 68196-544; 71335-0219; 55315-288; 49638-106; 68788-7743; 68016-243; 59556-854; 68210-4125; 47682-115; 69842-258; 50580-509; 49348-325; 41163-500; 69842-311; 70000-0305; 50090-2588; 61474-4265; 68998-300; 58103-115; 66689-055; 55910-282; 55670-468; 56062-946; 25000-901; 33992-0282; 69732-001; 47682-175; 49348-730; 36800-202; 67046-023; 41163-888; 55910-021; 36800-397; 50844-255; 71205-263; 70518-1855; 37808-747; 55910-010; 69842-322; 71309-001; 56062-161; 36800-414; 63187-968; 0113-7544; 0121-0966; 49314-1763; 54738-040; 29485-7003; 30142-591; 55319-494; 50844-751; 68210-4168; 51824-049; 36800-455; 42681-7076; 49580-0682; 59779-350; 41520-818; 69842-544; 0406-0422; 49999-131; 10202-701; 70120-023; 0135-0539; 61919-271; 69477-000; 0113-7130; 46122-630; 62011-0002; 68210-3100; 69676-0041; 72288-175; 41520-990; 50580-490; 10135-152; 76281-328; 68196-919; 60760-453; 62011-0460; 50580-579; 50580-600; 63029-620; 69842-073; 79903-032; 25000-071; 54859-809; 61245-145; 11673-966; 53604-701; 69842-390; 0781-3156; 50580-783; 46122-696; 50090-5469; 71335-0524; 0363-0959; 58103-124; 0485-0057; 0406-7845; 33992-0175; 63868-129; 70518-2798; 0363-9798; 69842-915; 72036-098; 23155-202; 41250-802; 69842-223; 72036-170; 47682-009; 11673-105; 67060-210; 50580-460; 49035-042; 72288-766; 58602-204; 69732-002; 55794-101; 72476-185; 69168-418; 66715-6708; 36800-900; 50580-692; 69842-780; 41250-650; 0113-0161; 11673-841; 0363-0531; 66715-6837
Synonyms Acetaminophen | Acetominophen | Hydroxyacetanilide | APAP | p-Acetamidophenol | p-Hydroxyacetanilide | Paracetamol | N-(4-Hydroxyphenyl)acetanilide | Acetamidophenol | N-Acetyl-p-aminophenol | Acephen | Acetaco | Tylenol | Anacin-3 | Anacin 3 | Anacin3 | Datril | Panadol | Acamol | Algotropyl
Chemical Information
Molecular Formula C8H9NO2
CAS Registry Number 103-90-2
SMILES CC(=O)NC1=CC=C(C=C1)O
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hyperreflexia17.02.01.002--Not Available
Hypersensitivity10.01.03.0030.000268%
Hypertension24.08.02.0010.000401%
Hypervolaemia14.05.06.003--Not Available
Hypoaesthesia17.02.06.023--Not Available
Hypoalbuminaemia09.01.02.003; 14.10.01.002--
Hypoglycaemia05.06.03.001; 14.06.03.0010.000087%
Hypokalaemia14.05.03.0020.000401%
Hypomagnesaemia14.04.02.001--
Hypophosphataemia14.04.03.0010.000134%
Hypotension24.06.03.0020.001204%
Hypothermia08.05.01.003; 12.05.03.0010.000268%
Hypotonia15.05.04.008; 17.05.02.002--Not Available
Hypoxia22.02.02.003--
Immune system disorder10.02.01.001--Not Available
Infection11.01.08.0020.000052%Not Available
Injection site pain08.02.03.010; 12.07.03.011--Not Available
Injection site reaction08.02.03.014; 12.07.03.015--
Insomnia17.15.03.002; 19.02.01.0020.000334%
Intentional self-injury12.01.08.036; 19.12.01.0020.000736%Not Available
International normalised ratio abnormal13.01.02.0290.000134%Not Available
Irritability08.01.03.011; 19.04.02.013--
Jaundice01.06.04.004; 09.01.01.004; 23.03.03.0300.000268%Not Available
Jaundice neonatal01.06.04.006; 09.01.01.008; 18.04.08.0010.000201%Not Available
Laceration12.01.06.006; 23.03.11.0040.000134%Not Available
Lactic acidosis14.01.01.0020.000201%Not Available
Lethargy08.01.01.008; 17.02.04.003; 19.04.04.0040.000535%
Leukocytosis01.02.01.0020.000201%
Leukopenia01.02.02.0010.000201%Not Available
Lip swelling07.05.04.005; 10.01.05.005; 23.04.01.0070.000134%Not Available
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ADReCS-Target
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