Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Acenocoumarol
Drug ID BADD_D00022
Description Acenocoumarol is a coumarin derivative used as an anticoagulant. Coumarin derivatives inhibit the reduction of vitamin K by vitamin K reductase. This prevents carboxylation of vitamin K-dependent clotting factors, II, VII, IX and X, and interferes with coagulation.[A188739] Hematocrit, hemoglobin, international normalized ratio and liver panel should be monitored. Patients on acenocoumarol are prohibited from giving blood.
Indications and Usage For the treatment and prevention of thromboembolic diseases. More specifically, it is indicated for the prevention of cerebral embolism, deep vein thrombosis, pulmonary embolism, thromboembolism in infarction and transient ischemic attacks. It is used for the treatment of deep vein thrombosis and myocardial infarction.
Marketing Status approved; investigational
ATC Code B01AA07
DrugBank ID DB01418
KEGG ID D07064
MeSH ID D000074
PubChem ID 54676537
TTD Drug ID D05HFY
NDC Product Code Not Available
UNII I6WP63U32H
Synonyms Acenocoumarol | Nicoumalone | Acenocoumarin | Sinthrome | Synthrom | Syncoumar | Syncumar | Sinkumar | Sintrom | Mini-Sintrom | Mini Sintrom | MiniSintrom
Chemical Information
Molecular Formula C19H15NO6
CAS Registry Number 152-72-7
SMILES CC(=O)CC(C1=CC=C(C=C1)[N+](=O)[O-])C2=C(C3=CC=CC=C3OC2=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Alopecia23.02.02.001--
Body temperature increased13.15.01.001---
Coagulopathy01.01.02.001---
Dermatitis23.03.04.002---
Diarrhoea07.02.01.001--
Gastrointestinal disorder07.11.01.001---
Haematuria20.02.01.006; 21.10.01.018; 24.07.01.047--
Haemoglobin13.01.05.018---
Hepatocellular injury09.01.07.008---
Hypersensitivity10.01.03.003--
Melaena07.12.02.004; 24.07.02.013---
Nausea07.01.07.001--
Neoplasm16.16.02.001---
Skin exfoliation23.03.07.003---
Skin necrosis23.03.03.011---
Ulcer08.03.06.001---
Urticaria10.01.06.001; 23.04.02.001--
Vomiting07.01.07.003--
Protein C deficiency01.01.01.006; 03.15.01.003---
Haemorrhage24.07.01.002---
Haemobilia09.01.08.009; 24.07.01.049---
Abdominal symptom07.01.06.007---
Decreased appetite08.01.09.028; 14.03.01.005--
Liver injury09.01.07.022; 12.01.17.012---
Heavy menstrual bleeding21.01.03.005---
Intermenstrual bleeding21.01.01.015---
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