Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Abacavir succinate
Drug ID BADD_D00009
Description Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. Chemically, it is a synthetic carbocyclic nucleoside and is the enantiomer with 1S, 4R absolute configuration on the cyclopentene ring. In vivo, abacavir sulfate dissociates to its free base, abacavir.
Indications and Usage For the treatment of HIV-1 infection, in combination with other antiretroviral agents.
Marketing Status approved; investigational
ATC Code J05AF06
DrugBank ID DB01048
KEGG ID D02734
MeSH ID C106538
PubChem ID 9822500
TTD Drug ID D0A4IJ
NDC Product Code 55111-920; 72865-167; 50268-049; 31722-562; 70518-1274; 65862-073; 31722-557; 68084-021; 0904-6874; 64380-717; 69097-514
UNII 40FH6D8CHK
Synonyms abacavir | 1592U89 | abacavir sulfate | Ziagen | (1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-2-cyclopentene-1-methanol | abacavir succinate
Chemical Information
Molecular Formula C18H24N6O5
CAS Registry Number 168146-84-7
SMILES C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)C4CC(C=C4)CO.C(CC(=O)O)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gastrointestinal disorder07.11.01.001---
Gastrointestinal pain07.01.05.005--
Headache17.14.01.001--
Hepatic failure09.01.03.002--
Hyperlactacidaemia14.01.01.006---
Hypotension24.06.03.002--
Infection11.01.08.002---
Influenza like illness08.01.03.010--
Insomnia17.15.03.002; 19.02.01.002--
Lactic acidosis14.01.01.002---
Lethargy08.01.01.008; 17.02.04.003; 19.04.04.004--
Liver function test abnormal13.03.04.030---
Lymphadenopathy01.09.01.002---
Lymphopenia01.02.02.002---
Malaise08.01.01.003--
Mouth ulceration07.05.06.004---
Musculoskeletal pain15.03.04.007--
Myalgia15.05.02.001--
Nausea07.01.07.001--
Nervous system disorder17.02.10.001---
Neuropathy peripheral17.09.03.003---
Neutropenia01.02.03.004---
Oedema08.01.07.006; 14.05.06.010---
Pain08.01.08.004--
Pancreatitis07.18.01.001--
Paraesthesia17.02.06.005; 23.03.03.094--
Pharyngitis07.05.07.004; 11.01.13.003; 22.07.03.004--
Pneumonia11.01.09.003; 22.07.01.003---
Pruritus23.03.12.001--
Rash23.03.13.001---
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