Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name 2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetate
Drug ID BADD_D00004
Description A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin.
Indications and Usage For the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis, including the treatment of acute flares long-term management. Also for treatment of juvenile rheumatoid arthritis.
Marketing Status approved
ATC Code M01AB03; M02AA21
DrugBank ID DB00500
KEGG ID D00158; D02355
MeSH ID D014046
PubChem ID 5508
TTD Drug ID D09BHB
NDC Product Code Not Available
UNII D8K2JPN18B
Synonyms Tolmetin | Tolectin | Tolmetin Sodium, Anhydrous | Anhydrous Tolmetin Sodium | Tolmetin Sodium Anhydrous | Anhydrous, Tolmetin Sodium | Sodium Anhydrous, Tolmetin | McN-2559 | McN 2559 | McN2559 | Tolmetin Sodium | Sodium, Tolmetin | Tolmetin Sodium, Dihydrate | Dihydrate Tolmetin Sodium
Chemical Information
Molecular Formula C15H14NO3-
CAS Registry Number 26171-23-3
SMILES CC1=CC=C(C=C1)C(=O)C2=CC=C(N2C)CC(=O)[O-]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001---
Abdominal pain07.01.05.002--
Agranulocytosis01.02.03.001---
Anaphylactic shock10.01.07.002; 24.06.02.004---
Anaphylactoid reaction10.01.07.003; 24.06.03.007---
Asthenia08.01.01.001---
Blood pressure increased13.14.03.005---
Blood urea increased13.13.01.006---
Body temperature increased13.15.01.001---
Cardiac failure congestive02.05.01.002---
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.003---
Constipation07.02.02.001--
Diarrhoea07.02.01.001--
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Dyspepsia07.01.02.001--
Dysuria20.02.02.002--
Epistaxis22.04.03.001; 24.07.01.005--
Erythema multiforme10.01.03.015; 23.03.01.003--
Flatulence07.01.04.002--
Gastritis07.08.02.001--
Gastrointestinal haemorrhage07.12.02.001; 24.07.02.009---
Gastrointestinal pain07.01.05.005--
Glossitis07.14.01.001---
Haematuria20.02.01.006; 21.10.01.018; 24.07.01.047--
Haemolytic anaemia01.06.03.002---
Headache17.14.01.001--
Hepatitis09.01.07.004---
Lymphadenopathy01.09.01.002---
Nausea07.01.07.001--
Oedema08.01.07.006; 14.05.06.010---
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