Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Primary progressive aphasia
ADR ID BADD_A10763
ADR Hierarchy
17      Nervous system disorders
17.02      Neurological disorders NEC
17.02.03      Cortical dysfunction NEC
17.02.03.021      Primary progressive aphasia
19      Psychiatric disorders
19.21      Cognitive and attention disorders and disturbances
19.21.01      Specific cognitive ability disturbances
19.21.01.014      Primary progressive aphasia
Description A progressive form of dementia characterized by the global loss of language abilities and initial preservation of other cognitive functions. Fluent and nonfluent subtypes have been described. Eventually a pattern of global cognitive dysfunction, similar to ALZHEIMER DISEASE, emerges. Pathologically, there are no Alzheimer or PICK DISEASE like changes, however, spongiform changes of cortical layers II and III are present in the TEMPORAL LOBE and FRONTAL LOBE. (From Brain 1998 Jan;121(Pt 1):115-26) [MeSH]
MedDRA Code 10081268
MeSH ID D018888
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Primary progressive aphasia | Aphasia, Primary Progressive | Aphasias, Primary Progressive | Primary Progressive Aphasia | Primary Progressive Aphasias | Progressive Aphasia, Primary | Progressive Aphasias, Primary | Mesulam's Syndrome | Syndrome, Mesulam's | Mesulam Syndrome | Syndrome, Mesulam
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D02150Temozolomide0.000112%
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