Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Primary biliary cholangitis
ADR ID BADD_A10757
ADR Hierarchy
09      Hepatobiliary disorders
09.01      Hepatic and hepatobiliary disorders
09.01.04      Hepatic fibrosis and cirrhosis
09.01.04.010      Primary biliary cholangitis
10      Immune system disorders
10.04      Autoimmune disorders
10.04.09      Hepatic autoimmune disorders
10.04.09.004      Primary biliary cholangitis
Description FIBROSIS of the hepatic parenchyma due to obstruction of BILE flow (CHOLESTASIS) in the intrahepatic or extrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC; BILE DUCTS, EXTRAHEPATIC). Primary biliary cholangitis involves the destruction of small intra-hepatic bile ducts and bile secretion. Secondary biliary cholangitis is produced by prolonged obstruction of large intrahepatic or extrahepatic bile ducts from a variety of causes. [MeSH]
MedDRA Code 10080429
MeSH ID D008105
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Biliary cirrhosis primary | Charcot's cirrhosis | Chronic non-suppurative destructive cholangitis | Hanot's cirrhosis | Hypertrophic cirrhosis | PBC | Primary biliary cirrhosis | Todd's cirrhosis | Primary biliary cholangitis | Liver Cirrhosis, Biliary | Liver Cirrhoses, Biliary | Biliary Cirrhosis | Cirrhosis, Biliary | Secondary Biliary Cholangitis | Biliary Cholangitis, Secondary | Cholangitis, Secondary Biliary | Secondary Biliary Cholangitides | Secondary Biliary Cirrhosis | Cirrhosis, Secondary Biliary | Biliary Cirrhosis, Secondary | Liver Cirrhosis, Obstructive | Obstructive Liver Cirrhosis | Primary Billiary Cholangitis | Billiary Cholangitis, Primary | Cholangitis, Primary Billiary | Primary Billiary Cholangitides | Biliary Cirrhosis, Primary, 1 | Biliary Cirrhosis, Primary | Cholangitis, Chronic Nonsuppurative Destructive | Primary Biliary Cirrhosis
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00121Amlodipine0.000006%
BADD_D00142Anastrozole0.000159%
BADD_D00285Bosentan0.000120%
BADD_D00680Dimethyl fumarate0.000600%
BADD_D01275Levofloxacin0.000063%
BADD_D01281Levonorgestrel0.000946%
BADD_D01336Macitentan0.000325%
BADD_D01418Methotrexate0.000364%
BADD_D01496Montelukast0.000015%
BADD_D01592Obeticholic acid0.004378%
BADD_D01835Pregabalin0.000078%
BADD_D02047Sodium oxybate0.000268%
BADD_D02105Tacrolimus0.000594%
BADD_D02236Tofacitinib0.000241%
BADD_D02436Atorvastatin--
BADD_D02464Fingolimod0.000241%
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