Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Immune thrombocytopenia
ADR ID BADD_A10109
ADR Hierarchy
10      Immune system disorders
10.02      Immune disorders NEC
10.02.01      Immune and associated conditions NEC
10.02.01.083      Immune thrombocytopenia
01      Blood and lymphatic system disorders
01.08      Platelet disorders
01.08.01      Thrombocytopenias
01.08.01.013      Immune thrombocytopenia
Description Thrombocytopenia occurring in the absence of toxic exposure or a disease associated with decreased platelets. It is mediated by immune mechanisms, in most cases IMMUNOGLOBULIN G autoantibodies which attach to platelets and subsequently undergo destruction by macrophages. The disease is seen in acute (affecting children) and chronic (adult) forms. [MeSH]
MedDRA Code 10083842
MeSH ID D016553; D007293
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Idiopathic thrombocytopenic purpura | ITP | Autoimmune thrombocytopenia | Idiopathic thrombocytopenia | Werlhof's syndrome | Immune-mediated thrombocytopenic purpura | Immune thrombocytopenic purpura | Refractory immune thrombocytopenic purpura | Persistent immune thrombocytopenic purpura | Secondary immune thrombocytopenic purpura | Primary immune thrombocytopenic purpura | Immune-mediated thrombocytopenia | Immune thrombocytopenia | Primary immune thrombocytopenia | Secondary immune thrombocytopenia | Purpura, Thrombocytopenic, Idiopathic | Idiopathic Thrombocytopenic Purpura | Idiopathic Thrombocytopenic Purpuras | Purpura, Idiopathic Thrombocytopenic | Purpuras, Idiopathic Thrombocytopenic | Thrombocytopenic Purpura, Idiopathic | Thrombocytopenic Purpuras, Idiopathic | Immune Thrombocytopenic Purpura | Immune Thrombocytopenic Purpuras | Purpura, Immune Thrombocytopenic | Purpuras, Immune Thrombocytopenic | Thrombocytopenic Purpura, Immune | Thrombocytopenic Purpuras, Immune | Immune Thrombocytopenia | Immune Thrombocytopenias | Thrombocytopenia, Immune | Thrombocytopenias, Immune | Thrombocytopenic Purpura, Autoimmune | Werlhof Disease | Disease, Werlhof | Werlhof's Disease | Disease, Werlhof's | Werlhofs Disease | Autoimmune Thrombocytopenia | Autoimmune Thrombocytopenias | Thrombocytopenia, Autoimmune | Thrombocytopenias, Autoimmune | Autoimmune Thrombocytopenic Purpura | Autoimmune Thrombocytopenic Purpuras | Purpura, Autoimmune Thrombocytopenic | Purpuras, Autoimmune Thrombocytopenic | Purpura, Thrombocytopenic, Autoimmune
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01295Linezolid0.002470%
BADD_D01322Losartan0.000050%
BADD_D01433Methylprednisolone0.000048%
BADD_D01449Metronidazole0.000026%
BADD_D01474Mipomersen sodium--
BADD_D01527Naltrexone--
BADD_D01528Naltrexone hydrochloride--
BADD_D01533Naproxen0.000019%
BADD_D01567Nilotinib0.000336%
BADD_D01601Olaparib0.000112%
BADD_D01633Oxaliplatin0.001287%
BADD_D01668Pantoprazole0.000090%
BADD_D01679Paroxetine--
BADD_D01765Phenytoin0.000191%
BADD_D01817Pramipexole0.000159%
BADD_D01831Prednisolone0.000175%
BADD_D01834Prednisone0.000031%
BADD_D01895Quinine--
BADD_D01896Quinine dihydrochloride--
BADD_D01897Quinine sulfate--
BADD_D01909Ramipril0.000186%
BADD_D01922Regorafenib0.000112%
BADD_D01933Ribavirin0.027691%
BADD_D01954Rivaroxaban0.000570%
BADD_D01971Rosuvastatin0.000034%
BADD_D01992Saxagliptin--
BADD_D02006Selexipag0.000082%
BADD_D02010Sertraline0.000032%
BADD_D02028Sirolimus0.000201%
BADD_D02047Sodium oxybate0.000268%
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