Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Central hypothyroidism
ADR ID BADD_A09648
ADR Hierarchy
05      Endocrine disorders
05.02      Thyroid gland disorders
05.02.03      Thyroid hypofunction disorders
05.02.03.009      Central hypothyroidism
14      Metabolism and nutrition disorders
14.11      Metabolism disorders NEC
14.11.01      Metabolic disorders NEC
14.11.01.049      Central hypothyroidism
Description A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction. [MeSH]
MedDRA Code 10086754
MeSH ID D007037
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Secondary hypothyroidism | Tertiary hypothyroidism | Pituitary hypothyroidism | Central hypothyroidism | Hypothyroidism | Hypothyroidisms | Primary Hypothyroidism | Hypothyroidism, Primary | Primary Hypothyroidisms | Thyroid-Stimulating Hormone Deficiency | Deficiency, Thyroid-Stimulating Hormone | Hormone Deficiency, Thyroid-Stimulating | Thyroid Stimulating Hormone Deficiency | Thyroid-Stimulating Hormone Deficiencies | TSH Deficiency | Deficiency, TSH | TSH Deficiencies | Secondary Hypothyroidism | Hypothyroidism, Secondary | Secondary Hypothyroidisms | Central Hypothyroidism | Central Hypothyroidisms | Hypothyroidism, Central
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00269Bexarotene0.000168%
BADD_D01765Phenytoin0.000191%
BADD_D02100Sunitinib0.000224%
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