Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term C3 glomerulopathy
ADR ID BADD_A09367
ADR Hierarchy
20      Renal and urinary disorders
20.05      Nephropathies
20.05.01      Glomerulonephritis and nephrotic syndrome
20.05.01.015      C3 glomerulopathy
10      Immune system disorders
10.02      Immune disorders NEC
10.02.01      Immune and associated conditions NEC
10.02.01.054      C3 glomerulopathy
Description Chronic glomerulonephritis characterized histologically by proliferation of MESANGIAL CELLS, increase in the MESANGIAL EXTRACELLULAR MATRIX, and a thickening of the glomerular capillary walls. This may appear as a primary disorder or secondary to other diseases including infections and autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Various subtypes are classified by their abnormal ultrastructures and immune deposits. Hypocomplementemia is a characteristic feature of all types of MPGN. | A type of mesangiocapillary glomerulonephritis that is characterized by subepithelial immune deposit and may be a variant of type I. | A type of mesangiocapillary glomerulonephritis that is characterized by immune deposits on the endothelial side of the GLOMERULAR BASEMENT MEMBRANE leading to splitting and reduplication of the basement membrane. | A type of mesangiocapillary glomerulonephritis that is characterized by the dark bands of electron-dense deposits in the GLOMERULAR BASEMENT MEMBRANE caused by autoantibodies against ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb). [MeSH]
MedDRA Code 10077827
MeSH ID D015432
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
C3 glomerulopathy | Dense deposit disease | C3 glomerulonephritis | Glomerulonephritis, Membranoproliferative | Glomerulonephritides, Membranoproliferative | Membranoproliferative Glomerulonephritides | Glomerulonephritis, Mesangiocapillary | Glomerulonephritides, Mesangiocapillary | Mesangiocapillary Glomerulonephritides | MPGN | Membranoproliferative Glomerulonephritis | Mesangiocapillary Glomerulonephritis | Glomerulonephritis, Hypocomplementemic | Glomerulonephritides, Hypocomplementemic | Hypocomplementemic Glomerulonephritides | Hypocomplementemic Glomerulonephritis | Membranoproliferative Glomerulonephritis, Type III | Membranoproliferative Glomerulonephritis, Type I | Subendothelial Membranoproliferative Glomerulonephritis | Membranoproliferative Glomerulonephritis, Subendothelial | Mesangiocapillary Glomerulonephritis, Type I | Membranoproliferative Glomerulonephritis, Type II | Dense Deposit Disease | Type II MPGN | Mesangiocapillary Glomerulonephritis, Type II | MPGNII | DDD MPGNII | Membranoproliferative Glomerulonephritis Type II
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01081Hydralazine0.000102%
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