Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Multiple system atrophy
ADR ID BADD_A08728
ADR Hierarchy
17      Nervous system disorders
17.02      Neurological disorders NEC
17.02.10      Nervous system disorders NEC
17.02.10.023      Multiple system atrophy
24      Vascular disorders
24.06      Decreased and nonspecific blood pressure disorders and shock
24.06.03      Vascular hypotensive disorders
24.06.03.013      Multiple system atrophy
Description A progressive neurodegenerative condition of the central and autonomic nervous systems characterized by atrophy of the preganglionic lateral horn neurons of the thoracic spinal cord. This disease is generally considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Affected individuals present in the fifth or sixth decade with ORTHOSTASIS and bladder dysfunction; and later develop FECAL INCONTINENCE; anhidrosis; ATAXIA; IMPOTENCE; and alterations of tone suggestive of basal ganglia dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p536) [MeSH]
MedDRA Code 10064060
MeSH ID D012791; D019578; D009849
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Shy-Drager syndrome | Olivopontocerebellar atrophy | Multiple system atrophy | Multiple system atrophy, cerebellar type | Multiple system atrophy, parkinsonian type | Shy-Drager Syndrome | Shy Drager Syndrome | Syndrome, Shy-Drager | Syndrome, Dysautonomia-Orthostatic Hypotension | Syndrome, Dysautonomia Orthostatic Hypotension | Orthostatic Hypotension, Dysautonomic | Dysautonomic Orthostatic Hypotension | Dysautonomic Orthostatic Hypotensions | Hypotension, Dysautonomic Orthostatic | Hypotensions, Dysautonomic Orthostatic | Orthostatic Hypotensions, Dysautonomic | Dysautonomia-Orthostatic Hypotension Syndrome | Dysautonomia Orthostatic Hypotension Syndrome | Dysautonomia-Orthostatic Hypotension Syndromes | Hypotension Syndrome, Dysautonomia-Orthostatic | Hypotension Syndromes, Dysautonomia-Orthostatic | Syndromes, Dysautonomia-Orthostatic Hypotension | Autonomic Failure, Progressive | Autonomic Failures, Progressive | Failure, Progressive Autonomic | Failures, Progressive Autonomic | Progressive Autonomic Failure | Progressive Autonomic Failures | Idiopathic Orthostatic Hypotension, Shy-Drager Type | Idiopathic Orthostatic Hypotension, Shy Drager Type
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00732Droxidopa0.000719%
BADD_D00891Fesoterodine0.000496%
BADD_D01304Lithium cation0.000192%
BADD_D01442Metoclopramide0.000431%
BADD_D02451Pimavanserin0.000131%
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