Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Secondary progressive multiple sclerosis
ADR ID BADD_A08688
ADR Hierarchy
17      Nervous system disorders
17.16      Demyelinating disorders
17.16.01      Multiple sclerosis acute and progressive
17.16.01.008      Secondary progressive multiple sclerosis
Description A form of multiple sclerosis characterized by a progressive deterioration in neurologic function which is in contrast to the more typical relapsing remitting form. If the clinical course is free of distinct remissions, it is referred to as primary progressive multiple sclerosis. When the progressive decline is punctuated by acute exacerbations, it is referred to as progressive relapsing multiple sclerosis. The term secondary progressive multiple sclerosis is used when relapsing remitting multiple sclerosis evolves into the chronic progressive form. (From Ann Neurol 1994;36 Suppl:S73-S79; Adams et al., Principles of Neurology, 6th ed, pp903-914) [MeSH]
MedDRA Code 10063400
MeSH ID D020528
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Secondary progressive multiple sclerosis | Multiple Sclerosis, Chronic Progressive | Chronic Progressive Multiple Sclerosis | Multiple Sclerosis, Progressive Relapsing | Multiple Sclerosis, Remittent Progressive | Remittent Progressive Multiple Sclerosis | Progressive Relapsing Multiple Sclerosis | Multiple Sclerosis, Secondary Progressive | Secondary Progressive Multiple Sclerosis | Multiple Sclerosis, Primary Progressive | Primary Progressive Multiple Sclerosis
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00680Dimethyl fumarate0.007241%
BADD_D02165Teriflunomide0.000844%
BADD_D02464Fingolimod0.007595%
BADD_D02473Sodium chloride--
BADD_D02511Siponimod0.000844%
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