Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Palmoplantar keratoderma
ADR ID BADD_A07529
ADR Hierarchy
23      Skin and subcutaneous tissue disorders
23.01      Cornification and dystrophic skin disorders
23.01.01      Hyperkeratoses
23.01.01.007      Palmoplantar keratoderma
Description Group of mostly hereditary disorders characterized by thickening of the palms and soles as a result of excessive keratin formation leading to hypertrophy of the stratum corneum (hyperkeratosis). [MeSH]
MedDRA Code 10033554
MeSH ID D007645
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Keratosis palmaris | Palmoplantar keratoderma | Tylosis palmaris | Hyperkeratosis palmaris and plantaris | Keratosis plantaris | Keratoderma, Palmoplantar | Keratodermas, Palmoplantar | Palmoplantar Keratodermas | Keratosis Palmaris et Plantaris | Palmoplantar Keratoderma | Hyperkeratosis Palmaris et Plantaris | Keratosis, Palmoplantar | Keratoses, Palmoplantar | Palmoplantar Keratoses | Palmoplantar Keratosis | Meleda Disease | Disease, Meleda | Keratosis Palmoplantaris Transgradiens of Siemens | Mal de Meleda | Meleda, Mal de | de Meleda, Mal
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00209Baclofen0.000070%
BADD_D00566Dabrafenib0.000414%
BADD_D00723Doxorubicin0.000112%
BADD_D00969Fosinoprilat0.007032%
BADD_D01922Regorafenib0.000907%
BADD_D02058Sorafenib0.000694%
BADD_D02344Vemurafenib0.000806%
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