Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term CREST syndrome
ADR ID BADD_A07125
ADR Hierarchy
24      Vascular disorders
24.03      Vascular disorders NEC
24.03.03      Vascular malformations and acquired anomalies
24.03.03.009      CREST syndrome
07      Gastrointestinal disorders
07.11      Gastrointestinal conditions NEC
07.11.02      Oesophageal disorders NEC
07.11.02.003      CREST syndrome
10      Immune system disorders
10.04      Autoimmune disorders
10.04.07      Scleroderma and associated disorders
10.04.07.003      CREST syndrome
23      Skin and subcutaneous tissue disorders
23.03      Epidermal and dermal conditions
23.03.02      Connective tissue disorders
23.03.02.013      CREST syndrome
15      Musculoskeletal and connective tissue disorders
15.06      Connective tissue disorders (excl congenital)
15.06.01      Connective tissue disorders NEC
15.06.01.010      CREST syndrome
Description A mild form of LIMITED SCLERODERMA, a multi-system disorder. Its features include symptoms of CALCINOSIS; RAYNAUD DISEASE; ESOPHAGEAL MOTILITY DISORDERS; sclerodactyly, and TELANGIECTASIS. When the defect in esophageal function is not prominent, it is known as CRST syndrome. [MeSH]
MedDRA Code 10011380
MeSH ID D017675
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
CREST syndrome | CRST syndrome | CREST Syndrome | CREST Syndromes | Syndrome, CREST | Calcinosis, Raynaud's phenomenon, Esophageal dismobility, Sclerodactyly, Telangiectasia Syndrome | CRST Syndrome | CRST Syndromes | Syndrome, CRST | Calcinosis-Raynaud Phenomenon-Sclerodactyly-Telangiectasia | Calcinosis Raynaud Phenomenon Sclerodactyly Telangiectasia | Phenomenon-Sclerodactyly-Telangiectasia, Calcinosis-Raynaud
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00285Bosentan0.000241%
BADD_D01336Macitentan0.000181%
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