Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Fructose intolerance
ADR ID BADD_A06674
ADR Hierarchy
07      Gastrointestinal disorders
07.17      Malabsorption conditions
07.17.01      Malabsorption syndromes
07.17.01.005      Fructose intolerance
14      Metabolism and nutrition disorders
14.02      Food intolerance syndromes
14.02.02      Sugar intolerance (excl glucose intolerance)
14.02.02.002      Fructose intolerance
Description An autosomal recessive fructose metabolism disorder due to deficient fructose-1-phosphate aldolase (EC 2.1.2.13) activity, resulting in accumulation of fructose-1-phosphate. The accumulated fructose-1-phosphate inhibits glycogenolysis and gluconeogenesis, causing severe hypoglycemia following ingestion of fructose. Prolonged fructose ingestion in infants leads ultimately to hepatic failure and death. Patients develop a strong distaste for sweet food, and avoid a chronic course of the disease by remaining on a fructose- and sucrose-free diet. [MeSH]
MedDRA Code 10072104
MeSH ID D005633
ADR Severity Grade (FAERS) Not Available
ADR Severity Grade (CTCAE) Not Available
Synonym
Fructose intolerance | Fructose Intolerance | Fructose Intolerances | Intolerance, Fructose | Intolerances, Fructose | Fructose Aldolase B Deficiency | Fructose Intolerance, Hereditary | Fructose Intolerances, Hereditary | Hereditary Fructose Intolerances | ALDOB Deficiency | ALDOB Deficiencies | Deficiencies, ALDOB | Deficiency, ALDOB | Fructose-1,6-Bisphosphate Aldolase B Deficiency | Fructose 1,6 Bisphosphate Aldolase B Deficiency | Fructose-1-Phosphate Aldolase Deficiency | Aldolase Deficiencies, Fructose-1-Phosphate | Aldolase Deficiency, Fructose-1-Phosphate | Deficiencies, Fructose-1-Phosphate Aldolase | Deficiency, Fructose-1-Phosphate Aldolase | Fructose 1 Phosphate Aldolase Deficiency | Fructose-1-Phosphate Aldolase Deficiencies | Fructosemia | Fructosemias | Hereditary Fructose Intolerance | Aldolase B Deficiency | Aldolase B Deficiencies | Deficiencies, Aldolase B | Deficiency, Aldolase B | Fructose-1,6-Biphosphate Aldolase Deficiency | Aldolase Deficiencies, Fructose-1,6-Biphosphate | Aldolase Deficiency, Fructose-1,6-Biphosphate | Deficiencies, Fructose-1,6-Biphosphate Aldolase | Deficiency, Fructose-1,6-Biphosphate Aldolase | Fructose 1,6 Biphosphate Aldolase Deficiency | Fructose-1,6-Biphosphate Aldolase Deficiencies
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00638Dextromethorphan--
The 1th Page    1    Total 1 Pages