Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Nephrogenic systemic fibrosis
ADR ID BADD_A06438
ADR Hierarchy
15      Musculoskeletal and connective tissue disorders
15.06      Connective tissue disorders (excl congenital)
15.06.01      Connective tissue disorders NEC
15.06.01.009      Nephrogenic systemic fibrosis
10      Immune system disorders
10.04      Autoimmune disorders
10.04.02      Skin autoimmune disorders NEC
10.04.02.007      Nephrogenic systemic fibrosis
23      Skin and subcutaneous tissue disorders
23.03      Epidermal and dermal conditions
23.03.02      Connective tissue disorders
23.03.02.012      Nephrogenic systemic fibrosis
20      Renal and urinary disorders
20.01      Renal disorders (excl nephropathies)
20.01.01      Renal failure complications
20.01.01.004      Nephrogenic systemic fibrosis
Description A chronic, acquired, idiopathic, progressive eruption of the skin that occurs in the context of RENAL FAILURE. It is sometimes accompanied by systemic fibrosis. The pathogenesis seems to be multifactorial, with postulated involvement of circulating fibrocytes. There is a strong association between this disorder and the use of gadolinium-based contrast agents. [MeSH]
MedDRA Code 10067467
MeSH ID D054989
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Nephrogenic fibrosing dermopathy | Nephrogenic systemic fibrosis | Nephrogenic Fibrosing Dermopathy | Dermopathies, Nephrogenic Fibrosing | Dermopathy, Nephrogenic Fibrosing | Fibrosing Dermopathies, Nephrogenic | Fibrosing Dermopathy, Nephrogenic | Nephrogenic Fibrosing Dermopathies | Nephrogenic Systemic Fibrosis | Fibroses, Nephrogenic Systemic | Fibrosis, Nephrogenic Systemic | Nephrogenic Systemic Fibroses | Systemic Fibroses, Nephrogenic | Systemic Fibrosis, Nephrogenic
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00776Eovist--
BADD_D00984Gadobutrol0.007113%
BADD_D00985Gadodiamide1.586285%
BADD_D00986Gadodiamide hydrate--
BADD_D00989Gadolinium--
BADD_D00990Gadolinium-dtpa--
BADD_D00991Gadopentetate dimeglumine--
BADD_D00993Gadoteridol0.028454%
BADD_D01345Magnevist--
BADD_D01621Optimark--
BADD_D02558Gadolinium cation (3+)-
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