Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Acute generalised exanthematous pustulosis
ADR ID BADD_A04733
ADR Hierarchy
10      Immune system disorders
10.01      Allergic conditions
10.01.01      Allergies to foods, food additives, drugs and other chemicals
10.01.01.034      Acute generalised exanthematous pustulosis
12      Injury, poisoning and procedural complications
12.03      Exposures, chemical injuries and poisoning
12.03.01      Poisoning and toxicity
12.03.01.005      Acute generalised exanthematous pustulosis
23      Skin and subcutaneous tissue disorders
23.03      Epidermal and dermal conditions
23.03.10      Pustular conditions
23.03.10.002      Acute generalised exanthematous pustulosis
11      Infections and infestations
11.07      Ancillary infectious topics
11.07.01      Inflammatory disorders following infection
11.07.01.018      Acute generalised exanthematous pustulosis
Description Rare skin eruption characterized by acute formation of pustules filled with NEUTROPHILS, fever, and peripheral blood LEUKOCYTOSIS. Most cases are associated with the use of antibiotics (e.g., BETA-LACTAMS). [MeSH]
MedDRA Code 10048799
MeSH ID D056150
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Toxic pustuloderma | Acute generalis. exematous pustul | AGEP | Acute generalised exanthematous pustulosis | Acute generalized exanthematous pustulosis | Photoinduced acute generalised exanthematous pustulosis | Photoinduced acute generalized exanthematous pustulosis | Acute localized exanthematous pustulosis | Acute localised exanthematous pustulosis | Bullous acute generalised exanthematous pustulosis | Bullous acute generalized exanthematous pustulosis | Acute Generalized Exanthematous Pustulosis | Pustulosis, Exanthematous, Acute Generalized | Acute Localized Exanthematous Pustulosis | Pustulosis, Exanthematous, Acute Localized
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01898Rabeprazole0.000260%
BADD_D01909Ramipril0.000233%
BADD_D01951Risperidone0.000546%
BADD_D01971Rosuvastatin0.000017%
BADD_D02010Sertraline0.000092%
BADD_D02029Sitagliptin0.000133%
BADD_D02066Spironolactone0.000037%
BADD_D02093Sulfasalazine0.000455%
BADD_D02150Temozolomide0.000280%
BADD_D02160Terbinafine0.003798%
BADD_D02161Terbinafine hydrochloride--
BADD_D02214Ticagrelor0.000408%
BADD_D02251Torsemide0.000683%
BADD_D02329Valproic acid0.000200%
BADD_D02332Vancomycin--
BADD_D02337Varenicline0.000487%
BADD_D02344Vemurafenib0.000302%
BADD_D02346Venlafaxine0.000032%
BADD_D02445Solifenacin0.000174%
BADD_D02490Apalutamide0.000667%
BADD_D02558Gadolinium cation (3+)-
BADD_D02560Iomeprol0.014227%
BADD_D02577Oseltamivir acid0.000496%
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