| ADR Ontology |
| ADR Term |
Upper motor neurone lesion |
| ADR ID |
BADD_A04421 |
| ADR Hierarchy |
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| Description |
Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089) [MeSH] |
| MedDRA Code |
10046298 |
| MeSH ID |
D016472
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ADR Severity Grade (FAERS)
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ADR Severity Grade (CTCAE)
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Not Available
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| Synonym |
| Primary lateral sclerosis | Upper motor neurone lesion | Upper motor neurone lesion NOS | Pronator drift | Pyramidal insufficiency | Motor Neuron Disease | Motor Neuron Diseases | Neuron Disease, Motor | Neuron Diseases, Motor | Motor System Disease | Motor System Diseases | Familial Motor Neuron Disease | Motor Neuron Disease, Familial | Lateral Sclerosis | Lateral Scleroses | Scleroses, Lateral | Sclerosis, Lateral | Primary Lateral Sclerosis | Lateral Scleroses, Primary | Lateral Sclerosis, Primary | Primary Lateral Scleroses | Scleroses, Primary Lateral | Sclerosis, Primary Lateral | Motor Neuron Disease, Upper | Upper Motor Neuron Disease | Motor Neuron Disease, Secondary | Secondary Motor Neuron Disease | Anterior Horn Cell Disease | Motor Neuron Disease, Lower | Lower Motor Neuron Disease |
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| Drugs Leading to the ADR |
| Drug ID | Drug Name | ADR Frequency (FAERS) | ADR Severity Grade (FAERS) | | BADD_D01465 | Miglustat | 0.004312% | | | BADD_D02247 | Topiramate | - | - |
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