Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Cystic fibrosis
ADR ID BADD_A01140
ADR Hierarchy
03      Congenital, familial and genetic disorders
03.16      Respiratory disorders congenital
03.16.01      Pulmonary and bronchial disorders congenital
03.16.01.002      Cystic fibrosis
22      Respiratory, thoracic and mediastinal disorders
22.03      Bronchial disorders (excl neoplasms)
22.03.01      Bronchospasm and obstruction
22.03.01.015      Cystic fibrosis
07      Gastrointestinal disorders
07.18      Exocrine pancreas conditions
07.18.03      Cystic pancreatic disorders
07.18.03.001      Cystic fibrosis
Description An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION. [MeSH]
MedDRA Code 10011762
MeSH ID D003550
ADR Severity Grade (FAERS) Not Available
ADR Severity Grade (CTCAE) Not Available
Synonym
Cystic fibrosis | Cystic fibrosis NOS | Cystic fibrosis without mention of meconium ileus | Mucoviscidosis | Cystic Fibrosis | Fibrosis, Cystic | Pulmonary Cystic Fibrosis | Cystic Fibrosis, Pulmonary | Pancreatic Cystic Fibrosis | Cystic Fibrosis, Pancreatic | Fibrocystic Disease of Pancreas | Pancreas Fibrocystic Disease | Pancreas Fibrocystic Diseases | Cystic Fibrosis of Pancreas
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00711Dornase alfa--
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